Y. Tokuda

Publication List Details

Period

1994 - 2009

Number

54

Co-Authors

A phase II dose-ranging study of palonosetron in Japanese patients receiving moderately emetogenic chemotherapy, including anthracycline and cyclophosphamide-based chemotherapy (2009)

Segawa, Y., Aogi, K., Inoue, K., Sano, M., Sekine, I., Tokuda, Y., ...

Background: The 5-HT3 receptor antagonists (RAs) help maintain the standard of care, in various combinations with other agents, for prevention of chemotherapy-induced nausea and vomiting (CINV)....

A simple prediction algorithm for bacteraemia in patients with acute febrile illness (2005)

Tokuda, Y., Miyasato, H., Stein, G.H.

Background: Existing prediction models for the risk of bacteraemia are complex and difficult to use. Physicians are likely to use a model only if it is simple and sensitive. Aim: To develop a simple...

A simple prediction algorithm for bacteraemia in patients with acute febrile illness (2005)

Tokuda, Y., Miyasato, H., Stein, G.H.

Background: Existing prediction models for the risk of bacteraemia are complex and difficult to use. Physicians are likely to use a model only if it is simple and sensitive. Aim: To develop a simple...

Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo.

Tokuda, Y, Tsuji, M, Yamazaki, M, Kimura, S, Abe, S, Yamaguchi, H

Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced...

Fundamental study on the mechanism of DNA degradation in tissues fixed in formaldehyde.

Tokuda, Y, Nakamura, T, Satonaka, K, Maeda, S, Doi, K, Baba, S, ...

The mechanism of DNA degradation and its clinical applications were examined. When purified lambda phage and extracted liver DNA were fixed in phosphate buffered formaldehyde, the DNA did not...

Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo.

Tokuda, Y, Tsuji, M, Yamazaki, M, Kimura, S, Abe, S, Yamaguchi, H

Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced...

Fundamental study on the mechanism of DNA degradation in tissues fixed in formaldehyde.

Tokuda, Y, Nakamura, T, Satonaka, K, Maeda, S, Doi, K, Baba, S, ...

The mechanism of DNA degradation and its clinical applications were examined. When purified lambda phage and extracted liver DNA were fixed in phosphate buffered formaldehyde, the DNA did not...

Evaluation of end of life care in cancer patients at a teaching hospital in Japan

Tokuda, Y, Nakazato, N, Tamaki, K

Objectives: To analyse the decision making for end of life care for patients with cancer at a teaching hospital in Japan at two periods 10 years apart.

Pupillary evaluation for differential diagnosis of coma

Tokuda, Y, Nakazato, N, Stein, G

Objectives: To determine the usefulness of bedside evaluation of pupils in determining the aetiology of coma by adopting a probabilistic approach.

Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumour immunotherapy.

Nakamura, Y., Tokuda, Y., Iwasawa, M., Tsukamoto, H., Kidokoro, M., Kobayashi, N., ...

A simple method for the rapid expansion of human CD4+ T cells with both helper and killer functions was established. CD4+ T cells separated from peripheral blood mononuclear cells using...

Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.

Ohnishi, Y., Nakamura, H., Yoshimura, M., Tokuda, Y., Iwasawa, M., Ueyama, Y., ...

A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined...

In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product.

Tokuda, Y., Ohnishi, Y., Shimamura, K., Iwasawa, M., Yoshimura, M., Ueyama, Y., ...

The c-erbB-2 product is thought to be a unique and useful target for antibody therapy of cancers overexpressing the c-erbB-2 gene. In vitro and in vivo anti-tumour effects of a humanised antibody...

Dose escalation and pharmacokinetic study of a humanized anti-HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

Tokuda, Y, Watanabe, T, Omuro, Y, Ando, M, Katsumata, N, Okumura, A, ...

We conducted a phase I pharmacokinetic dose escalation study of a recombinant humanized anti-p185HER2 monoclonal antibody (MKC-454) in 18 patients with metastatic breast cancer refractory to...

Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome

Umemura, S, Shirane, M, Takekoshi, S, Kusakabe, T, Itoh, J, Egashira, N, ...

The purpose of the present study is to identify genes that contribute to cell proliferation or differentiation of breast cancers independent of signalling through the oestrogen receptor (ER) or human...