Beretta, L, Svitkin, Y V, Sonenberg, N
The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but...
The La autoantigen contains a dimerization domain that is essential for enhancing translation.
Craig, A W, Svitkin, Y V, Lee, H S, Belsham, G J, Sonenberg, N
The La autoantigen is an RNA-binding protein that is involved in initiation and termination of RNA polymerase III transcription. It also binds several viral RNAs, including those of poliovirus and...
Svitkin, Y V, Meerovitch, K, Lee, H S, Dholakia, J N, Kenan, D J, Agol, V I, ...
Initiation of poliovirus RNA translation by internal entry of ribosomes is believed to require the participation of trans-acting factors. The mechanism of action of these factors is poorly defined....
Svitkin, Y V, Pause, A, Sonenberg, N
The trans-activation response element (TAR) at the 5' end of the human immunodeficiency virus type 1 (HIV-1) mRNAs forms a stable hairpin structure which is a target for binding of the virally...
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Meerovitch, K, Svitkin, Y V, Lee, H S, Lejbkowicz, F, Kenan, D J, Chan, E K, ...
Translation initiation on poliovirus RNA occurs by internal binding of ribosomes to a sequence within the 5' untranslated region. We have previously characterized a HeLa cell protein, p52, that binds...
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
Beretta, L, Gingras, A C, Svitkin, Y V, Hall, M N, Sonenberg, N
The immunosuppressant drug rapamycin blocks progression of the cell cycle at the G1 phase in mammalian cells and yeast. Here we show that rapamycin inhibits cap-dependent, but not cap-independent,...
General RNA binding proteins render translation cap dependent.
Svitkin, Y V, Ovchinnikov, L P, Dreyfuss, G, Sonenberg, N
Translation in rabbit reticulocyte lysate is relatively independent of the presence of the mRNA m7G cap structure and the cap binding protein, eIF-4E. In addition, initiation occurs frequently at...
Svitkin, Y V, Pause, A, Haghighat, A, Pyronnet, S, Witherell, G, Belsham, G J, ...
Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome. elF4A possesses ATPase and RNA helicase...
Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.
Svitkin, Y V, Imataka, H, Khaleghpour, K, Kahvejian, A, Liebig, H D, Sonenberg, N
The eukaryotic mRNA 3' poly(A) tail and the 5' cap cooperate to synergistically enhance translation. This interaction is mediated, at least in part, by elF4G, which bridges the mRNA termini by...
Beretta, L, Svitkin, Y V, Sonenberg, N
The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but...
The La autoantigen contains a dimerization domain that is essential for enhancing translation.
Craig, A W, Svitkin, Y V, Lee, H S, Belsham, G J, Sonenberg, N
The La autoantigen is an RNA-binding protein that is involved in initiation and termination of RNA polymerase III transcription. It also binds several viral RNAs, including those of poliovirus and...
Svitkin, Y V, Meerovitch, K, Lee, H S, Dholakia, J N, Kenan, D J, Agol, V I, ...
Initiation of poliovirus RNA translation by internal entry of ribosomes is believed to require the participation of trans-acting factors. The mechanism of action of these factors is poorly defined....
Svitkin, Y V, Pause, A, Sonenberg, N
The trans-activation response element (TAR) at the 5' end of the human immunodeficiency virus type 1 (HIV-1) mRNAs forms a stable hairpin structure which is a target for binding of the virally...
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Meerovitch, K, Svitkin, Y V, Lee, H S, Lejbkowicz, F, Kenan, D J, Chan, E K, ...
Translation initiation on poliovirus RNA occurs by internal binding of ribosomes to a sequence within the 5' untranslated region. We have previously characterized a HeLa cell protein, p52, that binds...
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
Beretta, L, Gingras, A C, Svitkin, Y V, Hall, M N, Sonenberg, N
The immunosuppressant drug rapamycin blocks progression of the cell cycle at the G1 phase in mammalian cells and yeast. Here we show that rapamycin inhibits cap-dependent, but not cap-independent,...
General RNA binding proteins render translation cap dependent.
Svitkin, Y V, Ovchinnikov, L P, Dreyfuss, G, Sonenberg, N
Translation in rabbit reticulocyte lysate is relatively independent of the presence of the mRNA m7G cap structure and the cap binding protein, eIF-4E. In addition, initiation occurs frequently at...
Svitkin, Y V, Pause, A, Haghighat, A, Pyronnet, S, Witherell, G, Belsham, G J, ...
Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome. elF4A possesses ATPase and RNA helicase...
Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.
Svitkin, Y V, Imataka, H, Khaleghpour, K, Kahvejian, A, Liebig, H D, Sonenberg, N
The eukaryotic mRNA 3' poly(A) tail and the 5' cap cooperate to synergistically enhance translation. This interaction is mediated, at least in part, by elF4G, which bridges the mRNA termini by...