Ya-Ching Hsieh

A Role of PPAR-γ in Androstenediol-Mediated Salutary Effects on Cardiac Function Following Trauma-Hemorrhage

Shimizu, Tomoharu, Szalay, László, Hsieh, Ya-Ching, Suzuki, Takao, Choudhry, Mashkoor A., Bland, Kirby I., ...

Although androstenediol (Adiol, a metabolite of dehydroepiandrosterone) improves cardiovascular function and attenuates proinflammatory cytokine production following trauma-hemorrhage, its mechanism...

Flutamide Attenuates Pro-inflammatory Cytokine Production and Hepatic Injury Following Trauma-Hemorrhage via Estrogen Receptor-related Pathway

Shimizu, Tomoharu, Yu, Huang-Ping, Hsieh, Ya-Ching, Choudhry, Mashkoor A., Suzuki, Takao, Bland, Kirby I., ...

Although flutamide attenuates hepatic injury following trauma-hemorrhage, the mechanisms of its salutary effects are unknown. This study suggests that the flutamide mediates its salutary effects on...

G Protein-Coupled Receptor 30-Dependent Protein Kinase A Pathway Is Critical in Nongenomic Effects of Estrogen in Attenuating Liver Injury after Trauma-Hemorrhage

Hsieh, Ya-Ching, Yu, Huang-Ping, Frink, Michael, Suzuki, Takao, Choudhry, Mashkoor A., Schwacha, Martin G., ...

Although nongenomic effects of 17β-estradiol (E2) are mediated via the estrogen receptor α (ER-α), the existence of another novel ER, G protein-coupled receptor 30 (GPR30), has been suggested as a...

The PI3K/Akt Pathway Mediates the Nongenomic Cardioprotective Effects of Estrogen Following Trauma-hemorrhage

Yu, Huang-Ping, Hsieh, Ya-Ching, Suzuki, Takao, Choudhry, Mashkoor A., Schwacha, Martin G., Bland, Kirby I., ...

17β-Estradiol-BSA improved cardiac function following trauma-hemorrhage. The decreased cardiomyocyte PI3K protein expression, Akt phosphorylation, and increased cardiomyocyte apoptosis were reversed...