Matsuoka, Sahoko, Oike, Yuichi, Onoyama, Ichiro, Iwama, Atsushi, Arai, Fumio, Takubo, Keiyo, ...
Common molecular machineries between hematopoietic stem cell (HSC) maintenance and leukemia prevention have been highlighted. The tumor suppressor Fbxw7 (F-box and WD-40 domain protein 7), a subunit...
Murata, Takashi, Kurokawa, Riki, Krones, Anna, Tatsumi, Ken, Ishii, Masami, Taki, Tomohiko, ...
CREB-binding protein (CBP) is a transcriptional coactivator that has intrinsic histone acetyltransferase (HAT) activity. CBP is the causative gene of Rubinstein–Taybi syndrome (RTS). To investigate...
Preliminary Phase II Study of Aclacinomycin A in Patients With Adult Acute Leukemia (1981)
SAMPI, KAZUMI, ABE, ROKUO, HAYASHI, YASUHIDE, HATTORI, MASAO
Seventeen patients with adult acute leukemia in relapse were treated with aclacinomycin A in 5-day courses given at a dose of 90 to 210 mg/m2/5 days as a daily bolus injection. Complete...
Taki, Tomohiko, Kano, Hirotsugu, Taniwaki, Masafumi, Sako, Masahiro, Yanagisawa, Masayoshi, Hayashi, Yasuhide
Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10−/CD19+) and poor treatment outcome. The t(4;11), creating MLL-AF4 chimeric...
Kitabayashi, Issay, Ida, Kohmei, Morohoshi, Fumiko, Yokoyama, Akihiko, Mitsuhashi, Naoko, Shimizu, Kimiko, ...
The AML1-CBFβ transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. In the...
Mammalian Septins Nomenclature
Macara, Ian G., Baldarelli, Richard, Field, Christine M., Glotzer, Michael, Hayashi, Yasuhide, Hsu, Shu-Chan, ...
There are 10 known mammalian septin genes, some of which produce multiple splice variants. The current nomenclature for the genes and gene products is very confusing, with several different names...
Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...
The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...
Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...
AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....
Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...
Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...
Yang, Hong Wei, Chen, Ying Zhang, Piao, Hui Ying, Takita, Junko, Soeda, Eiichi, Hayashi, Yasuhide
Recently, loss of heterozygosity (LOH) studies suggest that more than two tumor suppressor genes lie on the short arm of chromosome 1 (1p) in neuroblastoma (NB). To identify candidate tumor...
Codon 201Gly Polymorphic Type of the DCC Gene is Related to Disseminated Neuroblastoma1
Kong, Xiao-Tang, Choi, Seung Hoon, Bessho, Fumio, Kobayashi, Miyuki, Hanada, Ryoji, Yamamoto, Keiko, ...
The deleted in colorectal carcinoma (DCC) gene is a potential tumor-suppressor gene on chromosome 18q21.3. The relatively high frequency of loss of heterozygosity (LOH) and loss of expression of this...
Taki, Tomohiko, Kano, Hirotsugu, Taniwaki, Masafumi, Sako, Masahiro, Yanagisawa, Masayoshi, Hayashi, Yasuhide
Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10−/CD19+) and poor treatment outcome. The t(4;11), creating MLL-AF4 chimeric...
Kitabayashi, Issay, Ida, Kohmei, Morohoshi, Fumiko, Yokoyama, Akihiko, Mitsuhashi, Naoko, Shimizu, Kimiko, ...
The AML1-CBFβ transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. In the...
Mammalian Septins Nomenclature
Macara, Ian G., Baldarelli, Richard, Field, Christine M., Glotzer, Michael, Hayashi, Yasuhide, Hsu, Shu-Chan, ...
There are 10 known mammalian septin genes, some of which produce multiple splice variants. The current nomenclature for the genes and gene products is very confusing, with several different names...
Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...
The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...
Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...
AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....
Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...
Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...
Yang, Hong Wei, Chen, Ying Zhang, Piao, Hui Ying, Takita, Junko, Soeda, Eiichi, Hayashi, Yasuhide
Recently, loss of heterozygosity (LOH) studies suggest that more than two tumor suppressor genes lie on the short arm of chromosome 1 (1p) in neuroblastoma (NB). To identify candidate tumor...
Codon 201Gly Polymorphic Type of the DCC Gene is Related to Disseminated Neuroblastoma1
Kong, Xiao-Tang, Choi, Seung Hoon, Bessho, Fumio, Kobayashi, Miyuki, Hanada, Ryoji, Yamamoto, Keiko, ...
The deleted in colorectal carcinoma (DCC) gene is a potential tumor-suppressor gene on chromosome 18q21.3. The relatively high frequency of loss of heterozygosity (LOH) and loss of expression of this...
An atypical protein kinase C, PKC ζ, regulates human eosinophil effector functions
Kato, Masahiko, Yamaguchi, Takafumi, Tachibana, Atsushi, Suzuki, Masato, Izumi, Takashi, Maruyama, Kenichi, ...
Protein kinase (PK) C comprises a family of isoenzymes that play key roles in downstream signalling and cell functions. We studied PKC ζ participation in the effector functions of human eosinophils...
Matsuoka, Sahoko, Oike, Yuichi, Onoyama, Ichiro, Iwama, Atsushi, Arai, Fumio, Takubo, Keiyo, ...
Common molecular machineries between hematopoietic stem cell (HSC) maintenance and leukemia prevention have been highlighted. The tumor suppressor Fbxw7 (F-box and WD-40 domain protein 7), a subunit...