Yasushi Ami

Pathogenicity of Hantaan Virus in Newborn Mice: Genetic Reassortant Study Demonstrating that a Single Amino Acid Change in Glycoprotein G1 Is Related to Virulence

Ebihara, Hideki, Yoshimatsu, Kumiko, Ogino, Michiko, Araki, Koichi, Ami, Yasushi, Kariwa, Hiroaki, ...

Two Hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11E10), were used to examine the pathogenesis of Hantaan virus infection in a mouse model...

Recovery of Pathogenic Measles Virus from Cloned cDNA

Takeda, Makoto, Takeuchi, Kaoru, Miyajima, Naoko, Kobune, Fumio, Ami, Yasushi, Nagata, Noriyo, ...

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...

Intravenous Inoculation of Replication-Deficient Recombinant Vaccinia Virus DIs Expressing Simian Immunodeficiency Virus Gag Controls Highly Pathogenic Simian-Human Immunodeficiency Virus in Monkeys

Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...

To be effective, a vaccine against human immunodeficiency virus type 1 (HIV-1) must induce virus-specific T-cell responses and it must be safe for use in humans. To address these issues, we developed...

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Yamakami, Kenji, Honda, Mitsuo, Takei, Masami, Ami, Yasushi, Kitamura, Noboru, Nishinarita, Susumu, ...

To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with...

Stringent Requirement for the C Protein of Wild-Type Measles Virus for Growth both In Vitro and in Macaques

Takeuchi, Kaoru, Takeda, Makoto, Miyajima, Naoko, Ami, Yasushi, Nagata, Noriyo, Suzaki, Yuriko, ...

The P gene of measles virus (MV) encodes the P protein and three accessory proteins (C, V, and R). However, the role of these accessory proteins in the natural course of MV infection remains unclear....

Priming-Boosting Vaccination with Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and a Nonreplicating Vaccinia Virus Recombinant Leads to Long-Lasting and Effective Immunity

Ami, Yasushi, Izumi, Yasuyuki, Matsuo, Kazuhiro, Someya, Kenji, Kanekiyo, Masaru, Horibata, Shigeo, ...

Virus-specific T-cell responses can limit immunodeficiency virus type 1 (HIV-1) transmission and prevent disease progression and so could serve as the basis for an affordable, safe, and effective...

LC16m8, a Highly Attenuated Vaccinia Virus Vaccine Lacking Expression of the Membrane Protein B5R, Protects Monkeys from Monkeypox

Saijo, Masayuki, Ami, Yasushi, Suzaki, Yuriko, Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, ...

The potential threat of smallpox as a bioweapon has led to the production and stockpiling of smallpox vaccine in some countries. Human monkeypox, a rare but important viral zoonosis endemic to...

Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection

Eda, Yasuyuki, Murakami, Toshio, Ami, Yasushi, Nakasone, Tadashi, Takizawa, Mari, Someya, Kenji, ...

In an accompanying report (Y. Eda, M. Takizawa, T. Murakami, H. Maeda, K. Kimachi, H. Yonemura, S. Koyanagi, K. Shiosaki, H. Higuchi, K. Makizumi, T. Nakashima, K. Osatomi, S. Tokiyoshi, S....

Pathogenicity of Hantaan Virus in Newborn Mice: Genetic Reassortant Study Demonstrating that a Single Amino Acid Change in Glycoprotein G1 Is Related to Virulence

Ebihara, Hideki, Yoshimatsu, Kumiko, Ogino, Michiko, Araki, Koichi, Ami, Yasushi, Kariwa, Hiroaki, ...

Two Hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11E10), were used to examine the pathogenesis of Hantaan virus infection in a mouse model...

Recovery of Pathogenic Measles Virus from Cloned cDNA

Takeda, Makoto, Takeuchi, Kaoru, Miyajima, Naoko, Kobune, Fumio, Ami, Yasushi, Nagata, Noriyo, ...

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...

Intravenous Inoculation of Replication-Deficient Recombinant Vaccinia Virus DIs Expressing Simian Immunodeficiency Virus Gag Controls Highly Pathogenic Simian-Human Immunodeficiency Virus in Monkeys

Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...

To be effective, a vaccine against human immunodeficiency virus type 1 (HIV-1) must induce virus-specific T-cell responses and it must be safe for use in humans. To address these issues, we developed...

Early Bone Marrow Hematopoietic Defect in Simian/Human Immunodeficiency Virus C2/1-Infected Macaques and Relevance to Advance of Disease

Yamakami, Kenji, Honda, Mitsuo, Takei, Masami, Ami, Yasushi, Kitamura, Noboru, Nishinarita, Susumu, ...

To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with...

Stringent Requirement for the C Protein of Wild-Type Measles Virus for Growth both In Vitro and in Macaques

Takeuchi, Kaoru, Takeda, Makoto, Miyajima, Naoko, Ami, Yasushi, Nagata, Noriyo, Suzaki, Yuriko, ...

The P gene of measles virus (MV) encodes the P protein and three accessory proteins (C, V, and R). However, the role of these accessory proteins in the natural course of MV infection remains unclear....

Priming-Boosting Vaccination with Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and a Nonreplicating Vaccinia Virus Recombinant Leads to Long-Lasting and Effective Immunity

Ami, Yasushi, Izumi, Yasuyuki, Matsuo, Kazuhiro, Someya, Kenji, Kanekiyo, Masaru, Horibata, Shigeo, ...

Virus-specific T-cell responses can limit immunodeficiency virus type 1 (HIV-1) transmission and prevent disease progression and so could serve as the basis for an affordable, safe, and effective...

LC16m8, a Highly Attenuated Vaccinia Virus Vaccine Lacking Expression of the Membrane Protein B5R, Protects Monkeys from Monkeypox

Saijo, Masayuki, Ami, Yasushi, Suzaki, Yuriko, Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, ...

The potential threat of smallpox as a bioweapon has led to the production and stockpiling of smallpox vaccine in some countries. Human monkeypox, a rare but important viral zoonosis endemic to...

Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection

Eda, Yasuyuki, Murakami, Toshio, Ami, Yasushi, Nakasone, Tadashi, Takizawa, Mari, Someya, Kenji, ...

In an accompanying report (Y. Eda, M. Takizawa, T. Murakami, H. Maeda, K. Kimachi, H. Yonemura, S. Koyanagi, K. Shiosaki, H. Higuchi, K. Makizumi, T. Nakashima, K. Osatomi, S. Tokiyoshi, S....

An Attenuated Strain of Enterovirus 71 Belonging to Genotype A Showed a Broad Spectrum of Antigenicity with Attenuated Neurovirulence in Cynomolgus Monkeys▿

Arita, Minetaro, Nagata, Noriyo, Iwata, Naoko, Ami, Yasushi, Suzaki, Yuriko, Mizuta, Katsumi, ...

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also sometimes associated with serious neurological disorders. In this study, we characterized the antigenicity and...

Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model▿

Arita, Minetaro, Ami, Yasushi, Wakita, Takaji, Shimizu, Hiroyuki

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also associated with serious neurological disorders. An attenuated EV71 strain [EV71(S1-3′)] has been established...