Satoh, Takashi, Ishikawa, Osamu, Ihn, Hironobu, Endo, Hirahito, Kawaguchi, Yasushi, Sasaki, Tetsuo, ...
Objective. To evaluate the clinical usefulness of measuring anti-RNA polymerase (RNAP) III antibody with a commercially available ELISA in Japanese patients with SSc. Methods. This multicentre study...
Tanaka, Michiko, Sata, Tetsutaro, Kawaguchi, Yasushi
Abstract The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae . Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the...
Soejima, Makoto, Sugiura, Tomoko, Kawaguchi, Yasushi, Kawamoto, Manabu, Katsumata, Yasuhiro, Takagi, Kae, ...
Abstract Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with...
Kawaguchi, Yasushi, Tochimoto, Akiko, Hara, Masako, Kawamoto, Manabu, Sugiura, Tomoko, Katsumata, Yasuhiro, ...
Abstract Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis. One of several complications of SSc, pulmonary arterial hypertension (PAH) can be refractory to...
Kawamoto, Manabu, Harigai, Masayoshi, Hara, Masako, Kawaguchi, Yasushi, Tezuka, Katsunari, Tanaka, Michi, ...
Abstract Inducible co-stimulator (ICOS) is the third member of the CD28/cytotoxic T-lymphocyte associated antigen-4 family and is involved in the proliferation and activation of T cells. A detailed...
Sugiura, Tomoko, Maeno, Nobuaki, Kawaguchi, Yasushi, Takei, Syuji, Imanaka, Hiroyuki, Kawano, Yoshifumi, ...
Abstract Recently, we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still's disease (AOSD), which is characterized by...
Increased IL-15 production of muscle cells in polymyositis and dermatomyositis (2002)
Sugiura, Tomoko, Harigai, Masayoshi, Kawaguchi, Yasushi, Takagi, Kae, Fukasawa, Chikako, Ohsako-Higami, Satomi, ...
In polymyositis (PM)/dermatomyositis (DM), various cytokines, especially macrophage‐derived cytokines such as IL‐1α, IL‐1β and tumor necrosis factor (TNF)‐α, are expressed...
Van Sant, Charles, Kawaguchi, Yasushi, Roizman, Bernard
The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 is a promiscuous transactivator shown to enhance the expression of genes introduced into cells by infection or transfection. The...
Kawaguchi, Yasushi, Tanaka, Michiko, Yokoymama, Akihiko, Matsuda, Go, Kato, Kentaro, Kagawa, Hiroyuki, ...
The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 (HSV-1) is a promiscuous transactivator shown to enhance the expression of gene introduced into cells by infection or transfection. At...
Kawaguchi, Yasushi, Nakajima, Kaori, Igarashi, Mie, Morita, Tomoko, Tanaka, Michiko, Suzuki, Mikiko, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) consists of W1W2 repeats and a unique C-terminal Y1Y2 domain and has been suggested to play an important role in EBV-induced...
Kawaguchi, Yasushi, Matsumura, Tomio, Roizman, Bernard, Hirai, Kanji
Earlier reports (Y. Kawaguchi, R. Bruni, and B. Roizman, J. Virol. 71:1019–1024, 1997; Y. Kawaguchi, C. Van Sant, and B. Roizman, J. Virol. 72:1731–1736, 1998) showed that herpes simplex virus 1...
Kawaguchi, Yasushi, Van Sant, Charles, Roizman, Bernard
The translation elongation factor 1δ (EF-1δ) consists of two forms, a hypophosphorylated form (apparent Mr, 38,000) and a hyperphosphorylated form (apparent Mr, 40,000). Earlier Y. Kawaguchi, R....
Sonoda, Kengo, Sakaguchi, Masashi, Okamura, Hiroshi, Yokogawa, Kenji, Tokunaga, Eiji, Tokiyoshi, Sachio, ...
An earlier report (M. Sakaguchi et al., Vaccine 16:472–479, 1998) showed that recombinant Marek's disease virus type 1 (rMDV1) expressing the fusion (F) protein of Newcastle disease virus (NDV-F)...
Yokoyama, Akihiko, Tanaka, Michiko, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, Kawasaki, Hiroshi, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is a phosphoprotein suggested to play important roles in EBV-induced immortalization of B cells. One of the potential functions of...
Tanaka, Michiko, Yokoyama, Akihiko, Igarashi, Mie, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, ...
Self-association of viral proteins is important for many of their functions, including enzymatic, transcriptional, and transformational activities. Epstein-Barr virus (EBV) nuclear antigen leader...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Kawaguchi, Yasushi, Kato, Kentaro, Tanaka, Michiko, Kanamori, Mikiko, Nishiyama, Yukihiro, Yamanashi, Yuji
Earlier studies have shown that translation elongation factor 1δ (EF-1δ) is hyperphosphorylated in various mammalian cells infected with representative alpha-, beta-, and gammaherpesviruses and...
Doi, Yoshiharu, Kawaguchi, Yasushi, Nakamura, Yoshiyuki, Kunioka, Masao
The metabolic pathways of poly(3-hydroxybutyrate) (PHB) and polyphosphate in the microorganism Alcaligenes eutrophus H16 were studied by 1H, 13C, and 31P nuclear magnetic resonance (NMR) spectroscopy...
Kanamori, Mikiko, Watanabe, Shinya, Honma, Reiko, Kuroda, Masayuki, Imai, Shosuke, Takada, Kenzo, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) plays a critical role in transformation of primary B lymphocytes to continuously proliferating lymphoblastoid cell lines (LCLs). To...
Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
Kawaguchi, Yasushi, Hara, Masako, Wright, Timothy M.
It is reported that fibroblasts derived from clinically affected skin areas of patients with systemic sclerosis (SSc) have the ability to overproduce several cytokines and growth factors (i.e., IL-6,...
Herpes Simplex Virus Type 1 UL51 Protein Is Involved in Maturation and Egress of Virus Particles
Nozawa, Naoki, Kawaguchi, Yasushi, Tanaka, Michiko, Kato, Akihisa, Kato, Ai, Kimura, Hiroshi, ...
The UL51 gene of herpes simplex virus type 1 (HSV-1) encodes a phosphoprotein whose homologs are conserved throughout the herpes virus family. Recently, we reported that UL51 protein colocalizes with...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Kodaira, Hiroshi, Nishiyama, Yukihiro, Kawaguchi, Yasushi
We have developed a system to analyze the specific protein kinase activity of herpes simplex virus 1 Us3 in vitro and shown that Us3 directly phosphorylates viral proteins UL34, ICP22, and Us9 and...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Tanaka, Michiko, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
UL13 and Us3 are protein kinases encoded by herpes simplex virus 1. We report here that Us3 is a physiological substrate for UL13 in infected cells, based on the following observations. (i) The...
Sugiura, Tomoko, Maeno, Nobuaki, Kawaguchi, Yasushi, Takei, Syuji, Imanaka, Hiroyuki, Kawano, Yoshifumi, ...
Recently, we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still's disease (AOSD), which is characterized by...
Kawamoto, Manabu, Harigai, Masayoshi, Hara, Masako, Kawaguchi, Yasushi, Tezuka, Katsunari, Tanaka, Michi, ...
Inducible co-stimulator (ICOS) is the third member of the CD28/cytotoxic T-lymphocyte associated antigen-4 family and is involved in the proliferation and activation of T cells. A detailed functional...
Asai, Risa, Kato, Ai, Kato, Kentaro, Kanamori-Koyama, Mikiko, Sugimoto, Ken, Sairenji, Takeshi, ...
Epstein-Barr virus (EBV) BGLF4 is a viral protein kinase that is expressed in the lytic phase of infection and is packaged in virions. We report here that BGLF4 is a tegument protein that dissociates...
Van Sant, Charles, Kawaguchi, Yasushi, Roizman, Bernard
The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 is a promiscuous transactivator shown to enhance the expression of genes introduced into cells by infection or transfection. The...
Kawaguchi, Yasushi, Tanaka, Michiko, Yokoymama, Akihiko, Matsuda, Go, Kato, Kentaro, Kagawa, Hiroyuki, ...
The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 (HSV-1) is a promiscuous transactivator shown to enhance the expression of gene introduced into cells by infection or transfection. At...
Kawaguchi, Yasushi, Nakajima, Kaori, Igarashi, Mie, Morita, Tomoko, Tanaka, Michiko, Suzuki, Mikiko, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) consists of W1W2 repeats and a unique C-terminal Y1Y2 domain and has been suggested to play an important role in EBV-induced...
Kawaguchi, Yasushi, Matsumura, Tomio, Roizman, Bernard, Hirai, Kanji
Earlier reports (Y. Kawaguchi, R. Bruni, and B. Roizman, J. Virol. 71:1019–1024, 1997; Y. Kawaguchi, C. Van Sant, and B. Roizman, J. Virol. 72:1731–1736, 1998) showed that herpes simplex virus 1...
Kawaguchi, Yasushi, Van Sant, Charles, Roizman, Bernard
The translation elongation factor 1δ (EF-1δ) consists of two forms, a hypophosphorylated form (apparent Mr, 38,000) and a hyperphosphorylated form (apparent Mr, 40,000). Earlier Y. Kawaguchi, R....
Sonoda, Kengo, Sakaguchi, Masashi, Okamura, Hiroshi, Yokogawa, Kenji, Tokunaga, Eiji, Tokiyoshi, Sachio, ...
An earlier report (M. Sakaguchi et al., Vaccine 16:472–479, 1998) showed that recombinant Marek's disease virus type 1 (rMDV1) expressing the fusion (F) protein of Newcastle disease virus (NDV-F)...
Yokoyama, Akihiko, Tanaka, Michiko, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, Kawasaki, Hiroshi, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is a phosphoprotein suggested to play important roles in EBV-induced immortalization of B cells. One of the potential functions of...
Tanaka, Michiko, Yokoyama, Akihiko, Igarashi, Mie, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, ...
Self-association of viral proteins is important for many of their functions, including enzymatic, transcriptional, and transformational activities. Epstein-Barr virus (EBV) nuclear antigen leader...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Kawaguchi, Yasushi, Kato, Kentaro, Tanaka, Michiko, Kanamori, Mikiko, Nishiyama, Yukihiro, Yamanashi, Yuji
Earlier studies have shown that translation elongation factor 1δ (EF-1δ) is hyperphosphorylated in various mammalian cells infected with representative alpha-, beta-, and gammaherpesviruses and...
Doi, Yoshiharu, Kawaguchi, Yasushi, Nakamura, Yoshiyuki, Kunioka, Masao
The metabolic pathways of poly(3-hydroxybutyrate) (PHB) and polyphosphate in the microorganism Alcaligenes eutrophus H16 were studied by 1H, 13C, and 31P nuclear magnetic resonance (NMR) spectroscopy...
Kanamori, Mikiko, Watanabe, Shinya, Honma, Reiko, Kuroda, Masayuki, Imai, Shosuke, Takada, Kenzo, ...
Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) plays a critical role in transformation of primary B lymphocytes to continuously proliferating lymphoblastoid cell lines (LCLs). To...
Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
Kawaguchi, Yasushi, Hara, Masako, Wright, Timothy M.
It is reported that fibroblasts derived from clinically affected skin areas of patients with systemic sclerosis (SSc) have the ability to overproduce several cytokines and growth factors (i.e., IL-6,...
Herpes Simplex Virus Type 1 UL51 Protein Is Involved in Maturation and Egress of Virus Particles
Nozawa, Naoki, Kawaguchi, Yasushi, Tanaka, Michiko, Kato, Akihisa, Kato, Ai, Kimura, Hiroshi, ...
The UL51 gene of herpes simplex virus type 1 (HSV-1) encodes a phosphoprotein whose homologs are conserved throughout the herpes virus family. Recently, we reported that UL51 protein colocalizes with...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Kodaira, Hiroshi, Nishiyama, Yukihiro, Kawaguchi, Yasushi
We have developed a system to analyze the specific protein kinase activity of herpes simplex virus 1 Us3 in vitro and shown that Us3 directly phosphorylates viral proteins UL34, ICP22, and Us9 and...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Tanaka, Michiko, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
UL13 and Us3 are protein kinases encoded by herpes simplex virus 1. We report here that Us3 is a physiological substrate for UL13 in infected cells, based on the following observations. (i) The...
Asai, Risa, Kato, Ai, Kato, Kentaro, Kanamori-Koyama, Mikiko, Sugimoto, Ken, Sairenji, Takeshi, ...
Epstein-Barr virus (EBV) BGLF4 is a viral protein kinase that is expressed in the lytic phase of infection and is packaged in virions. We report here that BGLF4 is a tegument protein that dissociates...
Sugiura, Tomoko, Maeno, Nobuaki, Kawaguchi, Yasushi, Takei, Syuji, Imanaka, Hiroyuki, Kawano, Yoshifumi, ...
Recently, we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still's disease (AOSD), which is characterized by...
Kawamoto, Manabu, Harigai, Masayoshi, Hara, Masako, Kawaguchi, Yasushi, Tezuka, Katsunari, Tanaka, Michi, ...
Inducible co-stimulator (ICOS) is the third member of the CD28/cytotoxic T-lymphocyte associated antigen-4 family and is involved in the proliferation and activation of T cells. A detailed functional...
Kawaguchi, Yasushi, Tochimoto, Akiko, Hara, Masako, Kawamoto, Manabu, Sugiura, Tomoko, Katsumata, Yasuhiro, ...
Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis. One of several complications of SSc, pulmonary arterial hypertension (PAH) can be refractory to treatment,...
Kudoh, Ayumi, Daikoku, Tohru, Ishimi, Yukio, Kawaguchi, Yasushi, Shirata, Noriko, Iwahori, Satoko, ...
Induction of Epstein-Barr virus (EBV) lytic replication blocks chromosomal DNA replication notwithstanding an S-phase-like cellular environment with high cyclin-dependent kinase (CDK) activity. We...
Kawaguchi, Yasushi, Nishimagi, Emi, Tochimoto, Akiko, Kawamoto, Manabu, Katsumata, Yasuhiro, Soejima, Makoto, ...
The aberrant production of precursor IL-1α (pre-IL-1α) in skin fibroblasts that are derived from systemic sclerosis (SSc) is associated with the induction of IL-6 and procollagen, which contributes...
Soejima, Makoto, Sugiura, Tomoko, Kawaguchi, Yasushi, Kawamoto, Manabu, Katsumata, Yasuhiro, Takagi, Kae, ...
Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this...
Garibal, Julie, Hollville, Émilie, Bell, Andrew I., Kelly, Gemma L., Renouf, Benjamin, Kawaguchi, Yasushi, ...
The Epstein-Barr virus (EBV)-encoded leader protein, EBNA-LP, strongly activates the EBNA2-mediated transcriptional activation of cellular and viral genes and is therefore important for EBV-induced...
Iwahori, Satoko, Shirata, Noriko, Kawaguchi, Yasushi, Weller, Sandra K., Sato, Yoshitaka, Kudoh, Ayumi, ...
The ataxia telangiectasia-mutated (ATM) protein, a member of the related phosphatidylinositol 3-like kinase family encoded by a gene responsible for the human genetic disorder ataxia telangiectasia,...
Sugimoto, Ken, Uema, Masashi, Sagara, Hiroshi, Tanaka, Michiko, Sata, Tetsutaro, Hashimoto, Yasuhiro, ...
We report here the construction of a triply fluorescent-tagged herpes simplex virus 1 (HSV-1) expressing capsid protein VP26, tegument protein VP22, and envelope protein gB as fusion proteins with...
Kato, Akihisa, Tanaka, Michiko, Yamamoto, Mayuko, Asai, Risa, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
Us3 is a serine/threonine protein kinase encoded by herpes simplex virus 1 (HSV-1). Here, we report the identification of a physiological Us3 phosphorylation site on serine at position 147 (Ser-147)...
Tanaka, Michiko, Sata, Tetsutaro, Kawaguchi, Yasushi
The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae. Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the involvement...
Konno, Hiroyasu, Yamamoto, Takuya, Yamazaki, Kohsuke, Gohda, Jin, Akiyama, Taishin, Semba, Kentaro, ...
Kato, Akihisa, Arii, Jun, Shiratori, Ikuo, Akashi, Hiroomi, Arase, Hisashi, Kawaguchi, Yasushi
Us3 is a serine-threonine protein kinase encoded by herpes simplex virus 1 (HSV-1). As reported here, we attempted to identify the previously unreported physiological substrate of Us3 in...
Wisner, Todd W., Wright, Catherine C., Kato, Akihisa, Kawaguchi, Yasushi, Mou, Fan, Baines, Joel D., ...
Herpesvirus capsids collect along the inner surface of the nuclear envelope and bud into the perinuclear space. Enveloped virions then fuse with the outer nuclear membrane (NM). We previously showed...
Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing
Nojima, Takayuki, Oshiro-Ideue, Takako, Nakanoya, Hiroto, Kawamura, Hidenobu, Morimoto, Tomomi, Kawaguchi, Yasushi, ...
Viruses use alternative splicing to produce a broad series of proteins from small genomes by utilizing the cellular splicing machinery. Since viruses use cellular RNA binding proteins for viral RNA...
Arii, Jun, Uema, Masashi, Morimoto, Tomomi, Sagara, Hiroshi, Akashi, Hiroomi, Ono, Etsuro, ...
Herpes simplex virus 1 (HSV-1) enters cells either via fusion of the virion envelope and host cell plasma membrane or via endocytosis, depending on the cell type. In the study reported here, we...