Yasushi Okada

Intra-cellular transport of single-headed molecular motors KIF1A (2005)

Nishinari, Katsuhiro, Okada, Yasushi, Schadschneider, Andreas, Chowdhury, Debashish

Motivated by experiments on single-headed kinesin KIF1A, we develop a model of intra-cellular transport by interacting molecular motors. It captures explicitly not only the effects of ATP hydrolysis,...

Isolation of a cDNA for nodule-enhanced phosphoenolpyruvate carboxylase from pea and its expression in effective and plant-determined ineffective pea nodules (1997)

Suganuma, Norio, Okada, Yasushi, Kanayama, Yoshinori

A cDNA clone for phosphoenolpyruvate carboxylase (PEPC) was isolated from nodules of pea (Pisum sativum L.). The levels of activity, the PEPC polypeptide and the mRNA for PEPC in effective nodules...

Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion (1995)

Hamann, Gerhard F., Okada, Yasushi, Fitridge, Robert A., Del Zoppo, Gregory J.

Background and Purpose Changes in vascular permeability are well-known and important consequences of cerebral ischemia. The development of edema and of petechial hemorrhage is connected to altered...

Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion (1995)

Hamann, Gerhard F., Okada, Yasushi, Fitridge, Robert A., Del Zoppo, Gregory J.

Background and Purpose Changes in vascular permeability are well-known and important consequences of cerebral ischemia. The development of edema and of petechial hemorrhage is connected to altered...

Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin

Okada, Yasushi, Hirokawa, Nobutaka

A motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was demonstrated to take more than 600 steps before detaching from a microtubule. However, its molecular mechanism...

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome

Nakagawa, Terunaga, Tanaka, Yosuke, Matsuoka, Eiji, Kondo, Satoru, Okada, Yasushi, Noda, Yasuko, ...

KIF (kinesin superfamily) proteins are microtubule-dependent molecular motors that play important roles in intracellular transport and cell division. The extent to which KIFs are involved in various...

Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein

Kim, Wankee, Tang, Yao, Okada, Yasushi, Torrey, Ted A., Chattopadhyay, Sisir K., Pfleiderer, Michael, ...

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C...

Nodal Cilia Dynamics and the Specification of the Left/Right Axis in Early Vertebrate Embryo Development

Buceta, Javier, Ibañes, Marta, Rasskin-Gutman, Diego, Okada, Yasushi, Hirokawa, Nobutaka, Izpisúa-Belmonte, Juan Carlos

Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is...

Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin

Okada, Yasushi, Hirokawa, Nobutaka

A motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was demonstrated to take more than 600 steps before detaching from a microtubule. However, its molecular mechanism...

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome

Nakagawa, Terunaga, Tanaka, Yosuke, Matsuoka, Eiji, Kondo, Satoru, Okada, Yasushi, Noda, Yasuko, ...

KIF (kinesin superfamily) proteins are microtubule-dependent molecular motors that play important roles in intracellular transport and cell division. The extent to which KIFs are involved in various...

Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein

Kim, Wankee, Tang, Yao, Okada, Yasushi, Torrey, Ted A., Chattopadhyay, Sisir K., Pfleiderer, Michael, ...

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C...

Nodal Cilia Dynamics and the Specification of the Left/Right Axis in Early Vertebrate Embryo Development

Buceta, Javier, Ibañes, Marta, Rasskin-Gutman, Diego, Okada, Yasushi, Hirokawa, Nobutaka, Izpisúa-Belmonte, Juan Carlos

Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is...

A standardized kinesin nomenclature

Lawrence, Carolyn J., Dawe, R. Kelly, Christie, Karen R., Cleveland, Don W., Dawson, Scott C., Endow, Sharyn A., ...

In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin...

Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A−/− Mice Analysis

Takeda, Sen, Yonekawa, Yoshiaki, Tanaka, Yosuke, Okada, Yasushi, Nonaka, Shigenori, Hirokawa, Nobutaka

KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a heterotrimeric KIF3 complex with KIF3B or...

Defect in Synaptic Vesicle Precursor Transport and Neuronal Cell Death in KIF1A Motor Protein–deficient Mice

Yonekawa, Yoshiaki, Harada, Akihiro, Okada, Yasushi, Funakoshi, Takeshi, Kanai, Yoshimitsu, Takei, Yosuke, ...

The nerve axon is a good model system for studying the molecular mechanism of organelle transport in cells. Recently, the new kinesin superfamily proteins (KIFs) have been identified as candidate...

KIFC3, a microtubule minus end–directed motor for the apical transport of annexin XIIIb–associated Triton-insoluble membranes

Noda, Yasuko, Okada, Yasushi, Saito, Nobuhito, Setou, Mitsutoshi, Xu, Ying, Zhang, Zheizeng, ...

We have identified and characterized a COOH-terminal motor domain–type kinesin superfamily protein (KIFC), KIFC3, in the kidney. KIFC3 is a minus end–directed microtubule motor protein, therefore...

Monetary and international factors behind Japan's lost decade

Hamada, Koichi, Okada, Yasushi

Most studies on Japan's "lost decade" have been broadly focused on its real and domestic aspects, such as total factory productivity (TPF), growth decline, non-performing loans, and governance. This...

Left–Right Determination: Involvement of Molecular Motor KIF3, Cilia, and Nodal Flow

Hirokawa, Nobutaka, Tanaka, Yosuke, Okada, Yasushi

Mammalian left–right determination is a good example for how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node,...