Yi-Chun Wang

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605 (2009)

Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, ...

Abstract Background The insulin-like growth factor (IGF) axis is an important signaling pathway in the growth and survival of many cell and tissue types. This pathway has also been implicated in many...

Shock waves in bubbly cavitating flows. Part I. Shock waves in cloud cavitation. Part II. Bubbly cavitating flows through a converging-diverging nozzle (2006)

Wang, Yi-Chun

Two problems are considered in this thesis: the nonlinear dynamics of a cloud of cavitation bubbles, and bubbly cavitating flows in a converging-diverging nozzle. The focus of the first problem is to...

Hydrodynamic Effects of Phase Relative Motion on Critical Bubbly Cavitating Flows Through a Converging-Diverging Nozzle (2001)

Wang, Yi-Chun, Chen, Ethan

One-dimensional bubbly flows through converging-diverging nozzles are investigated using a two-fluid model. Effects associated with both translational and radial relative motions between bubbles and...

Numerical Computation of Shock Waves in a Spherical Cloud of Cavitation Bubbles (1999)

Wang, Yi-Chun, Brennen, Christopher E.

The nonlinear dynamics of a spherical cloud of cavitation bubbles have been simulated numerically in order to learn more about the physical phenomena occurring in cloud cavitation. A finite cloud of...

One-Dimensional Bubbly Cavitating Flows Through a Converging-Diverging Nozzle (1998)

Wang, Yi-Chun, Brennen, C. E.

A nonbarotropic continuum bubbly mixture model is used to study the one-dimensional cavitating flow through a converging-diverging nozzle. The nonlinear dynamics of the cavitation bubbles are modeled...

One-Dimensional Bubbly Cavitating Flows through a Converging-Diverging Nozzle (1997)

Wang, Yi-Chun, Brennen, Christopher E.

A non-barotropic continuum bubbly mixture model is used to study the one-dimensional cavitating flow through a converging-diverging nozzle. The nonlinear dynamics of the cavitation bubbles are...

Shock waves in bubbly cavitating flows. Part I. Shock waves in cloud cavitation. Part II. Bubbly cavitating flows through a converging-diverging nozzle (1996)

Wang, Yi-Chun

Two problems are considered in this thesis: the nonlinear dynamics of a cloud of cavitation bubbles, and bubbly cavitating flows in a converging-diverging nozzle. The focus of the first problem is to...

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Wang, Jieyi, Tucker, Lora A., Stavropoulos, Jason, Zhang, Qian, Wang, Yi-Chun, Bukofzer, Gail, ...

This laboratory and others have shown that agents that inhibit the in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angiogenesis and tumor growth in...