Yi-Guang Chen

Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression (2006)

Serreze, David V., Osborne, Melissa A., Chen, Yi-Guang, Chapman, Harold D., Pearson, Todd, Brehm, Michael A., ...

In both humans and NOD mice, particular combinations of MHC genes provide the primary risk factor for development of the autoreactive T cell responses causing type 1 diabetes (T1D). Conversely, other...

Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

Mukhopadhaya, Arunika, Hanafusa, Tadashi, Jarchum, Irene, Chen, Yi-Guang, Iwai, Yoshiko, Serreze, David V., ...

Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. Cytotoxic CD8+ T cells,...