Yohei Tominaga

A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome (2006)

Ohno, Mizuki, Miura, Tomofumi, Furuichi, Masato, Tominaga, Yohei, Tsuchimoto, Daisuke, Sakumi, Kunihiko, ...

8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its mutagenic potential. The steady-state...

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts (2004)

Ichinoe, Akimasa, Behmanesh, Mehrdad, Tominaga, Yohei, Ushijima, Yasuhiro, Hirano, Seiki, Sakai, Yasunari, ...

There are three types of mouse Mutyh mRNAs (type a, b and c) generated by alternative splicing, and type b mRNA is a major form among the three in most of the tissues examined. The level of type c...

MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain (2004)

Tominaga, Yohei, Ushijima, Yasuhiro, Tsuchimoto, Daisuke, Mishima, Masaki, Shirakawa, Masahiro, Hirano, Seiki, ...

MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. In cell-free extract prepared from the thymocytes of wild type but...

Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair (2004)

Hashimoto, Keiji, Tominaga, Yohei, Nakabeppu, Yusaku, Moriya, Masaaki

8-Oxo-7, 8-dihydrodeoxyguanosine (8-oxo-dG), one of the representative oxidative DNA lesions, frequently mispairs with the incoming dAMP during mammalian DNA replication. Mispaired dA is removed by...

ACCELERATED PAPER: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent (1996)

Tsuzuki, Teruhisa, Kunihiko, Sakumi, Shiraishi, Akiko, Kawate, Hisaya, Igarashi, Hisato, Iwakuma, Tomoo, ...

Alkylation of DNA at the O6-position of guanine is one of the most critical events leading to induction of mutation as well as to cancer. The enzyme O6-methylguanine-DNA methyltransferase repairs...

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, ...

Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among various classes of oxidative DNA damage,...

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

Ichinoe, Akimasa, Behmanesh, Mehrdad, Tominaga, Yohei, Ushijima, Yasuhiro, Hirano, Seiki, Sakai, Yasunari, ...

There are three types of mouse Mutyh mRNAs (type a, b and c) generated by alternative splicing, and type b mRNA is a major form among the three in most of the tissues examined. The level of type c...

MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain

Tominaga, Yohei, Ushijima, Yasuhiro, Tsuchimoto, Daisuke, Mishima, Masaki, Shirakawa, Masahiro, Hirano, Seiki, ...

MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. In cell-free extract prepared from the thymocytes of wild type but...

Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair

Hashimoto, Keiji, Tominaga, Yohei, Nakabeppu, Yusaku, Moriya, Masaaki

8-Oxo-7, 8-dihydrodeoxyguanosine (8-oxo-dG), one of the representative oxidative DNA lesions, frequently mispairs with the incoming dAMP during mammalian DNA replication. Mispaired dA is removed by...

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

Ushijima, Yasuhiro, Tominaga, Yohei, Miura, Tomofumi, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku

2-Hydroxy-2-deoxyadenosine triphosphate (2-OH-dATP), generated by the oxidation of dATP, can be misincorporated by DNA polymerases opposite guanine in template DNA during DNA replication, thus...

The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors

De Soto, Joseph A., Wang, Xianyan, Tominaga, Yohei, Wang, Rui-Hong, Cao, Liu, Qiao, Wenhui, ...

BRCA1 and BRCA2 mutations are responsible for most familial breast carcinomas. Recent reports carried out in non-cancerous mouse BRCA1- or BRCA2-deficient embryonic stem (ES) cells, and hamster...

Murine Wee1 Plays a Critical Role in Cell Cycle Regulation and Pre-Implantation Stages of Embryonic Development

Tominaga, Yohei, Li, Cuiling, Wang, Rui-Hong, Deng, Chu-Xia

Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila,...

A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome

Ohno, Mizuki, Miura, Tomofumi, Furuichi, Masato, Tominaga, Yohei, Tsuchimoto, Daisuke, Sakumi, Kunihiko, ...

8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its mutagenic potential. The steady-state...

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, ...

Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among various classes of oxidative DNA damage,...

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

Ichinoe, Akimasa, Behmanesh, Mehrdad, Tominaga, Yohei, Ushijima, Yasuhiro, Hirano, Seiki, Sakai, Yasunari, ...

There are three types of mouse Mutyh mRNAs (type a, b and c) generated by alternative splicing, and type b mRNA is a major form among the three in most of the tissues examined. The level of type c...

MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain

Tominaga, Yohei, Ushijima, Yasuhiro, Tsuchimoto, Daisuke, Mishima, Masaki, Shirakawa, Masahiro, Hirano, Seiki, ...

MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. In cell-free extract prepared from the thymocytes of wild type but...

Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair

Hashimoto, Keiji, Tominaga, Yohei, Nakabeppu, Yusaku, Moriya, Masaaki

8-Oxo-7, 8-dihydrodeoxyguanosine (8-oxo-dG), one of the representative oxidative DNA lesions, frequently mispairs with the incoming dAMP during mammalian DNA replication. Mispaired dA is removed by...

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

Ushijima, Yasuhiro, Tominaga, Yohei, Miura, Tomofumi, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku

2-Hydroxy-2-deoxyadenosine triphosphate (2-OH-dATP), generated by the oxidation of dATP, can be misincorporated by DNA polymerases opposite guanine in template DNA during DNA replication, thus...

A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome

Ohno, Mizuki, Miura, Tomofumi, Furuichi, Masato, Tominaga, Yohei, Tsuchimoto, Daisuke, Sakumi, Kunihiko, ...

8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its mutagenic potential. The steady-state...

The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors

De Soto, Joseph A., Wang, Xianyan, Tominaga, Yohei, Wang, Rui-Hong, Cao, Liu, Qiao, Wenhui, ...

BRCA1 and BRCA2 mutations are responsible for most familial breast carcinomas. Recent reports carried out in non-cancerous mouse BRCA1- or BRCA2-deficient embryonic stem (ES) cells, and hamster...

Murine Wee1 Plays a Critical Role in Cell Cycle Regulation and Pre-Implantation Stages of Embryonic Development

Tominaga, Yohei, Li, Cuiling, Wang, Rui-Hong, Deng, Chu-Xia

Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila,...

Contrasting Genome-Wide Distribution of 8-Hydroxyguanine and Acrolein-Modified Adenine during Oxidative Stress-Induced Renal Carcinogenesis

Akatsuka, Shinya, Aung, Than Tin, Dutta, Khokon Kumar, Jiang, Li, Lee, Wen-Hua, Liu, Yu-Ting, ...

Oxidative stress is a persistent threat to the genome and is associated with major causes of human mortality, including cancer, atherosclerosis, and aging. Here we established a method to generate...

Antagonistic Regulation of Cell-Matrix Adhesion by FosB and ΔFosB/Δ2ΔFosB Encoded by Alternatively Spliced Forms of fosB Transcripts

Ohnishi, Yoshinori N., Sakumi, Kunihiko, Yamazaki, Katsuhisa, Ohnishi, Yoko H., Miura, Tomofumi, Tominaga, Yohei, ...

Among fos family genes encoding components of activator protein-1 complex, only the fosB gene produces two forms of mature transcripts, namely fosB and ΔfosB mRNAs, by alternative splicing of an...