Yoshinobu Hara

Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly

Shishido-Hara, Yukiko, Hara, Yoshinobu, Larson, Theresa, Yasui, Kotaro, Nagashima, Kazuo, Stoner, Gerald L.

Human polyomavirus JC (JCV) can encode the three capsid proteins VP1, VP2, and VP3, downstream of the agnoprotein in the late region. JCV virions are identified in the nucleus of infected cells. In...

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

Üren, Deniz, Hwang, Hweung-Kon, Hara, Yoshinobu, Takeda, Kazuyo, Kawamoto, Sachiyo, Tullio, Antonella N., ...

Complete ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice resulted in cardiac and brain defects that were lethal during embryonic development or on the day of birth. In this paper, we...

A Point Mutation in the Motor Domain of Nonmuscle Myosin II-B Impairs Migration of Distinct Groups of Neurons

Ma, Xuefei, Kawamoto, Sachiyo, Hara, Yoshinobu, Adelstein, Robert S.

We generated mice harboring a single amino acid mutation in the motor domain of nonmuscle myosin heavy chain II-B (NMHC II-B). Homozygous mutant mice had an abnormal gait and difficulties in...

Major and Minor Capsid Proteins of Human Polyomavirus JC Cooperatively Accumulate to Nuclear Domain 10 for Assembly into Virions†

Shishido-Hara, Yukiko, Ichinose, Shizuko, Higuchi, Kayoko, Hara, Yoshinobu, Yasui, Kotaro

The human polyomavirus JC (JCV) replicates in the nuclei of infected cells. Here we report that JCV virions are efficiently assembled at nuclear domain 10 (ND10), which is also known as promyelocytic...

Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly

Shishido-Hara, Yukiko, Hara, Yoshinobu, Larson, Theresa, Yasui, Kotaro, Nagashima, Kazuo, Stoner, Gerald L.

Human polyomavirus JC (JCV) can encode the three capsid proteins VP1, VP2, and VP3, downstream of the agnoprotein in the late region. JCV virions are identified in the nucleus of infected cells. In...

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

Üren, Deniz, Hwang, Hweung-Kon, Hara, Yoshinobu, Takeda, Kazuyo, Kawamoto, Sachiyo, Tullio, Antonella N., ...

Complete ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice resulted in cardiac and brain defects that were lethal during embryonic development or on the day of birth. In this paper, we...

A Point Mutation in the Motor Domain of Nonmuscle Myosin II-B Impairs Migration of Distinct Groups of Neurons

Ma, Xuefei, Kawamoto, Sachiyo, Hara, Yoshinobu, Adelstein, Robert S.

We generated mice harboring a single amino acid mutation in the motor domain of nonmuscle myosin heavy chain II-B (NMHC II-B). Homozygous mutant mice had an abnormal gait and difficulties in...

Major and Minor Capsid Proteins of Human Polyomavirus JC Cooperatively Accumulate to Nuclear Domain 10 for Assembly into Virions†

Shishido-Hara, Yukiko, Ichinose, Shizuko, Higuchi, Kayoko, Hara, Yoshinobu, Yasui, Kotaro

The human polyomavirus JC (JCV) replicates in the nuclei of infected cells. Here we report that JCV virions are efficiently assembled at nuclear domain 10 (ND10), which is also known as promyelocytic...

Patterns of Neurogenesis and Amplitude of Reelin Expression Are Essential for Making a Mammalian-Type Cortex

Nomura, Tadashi, Takahashi, Masanori, Hara, Yoshinobu, Osumi, Noriko

The mammalian neocortex is characterized as a six-layered laminar structure, in which distinct types of pyramidal neurons are distributed coordinately during embryogenesis. In contrast, no other...

Arachidonic Acid Drives Postnatal Neurogenesis and Elicits a Beneficial Effect on Prepulse Inhibition, a Biological Trait of Psychiatric Illnesses

Maekawa, Motoko, Takashima, Noriko, Matsumata, Miho, Ikegami, Shiro, Kontani, Masanori, Hara, Yoshinobu, ...

Prepulse inhibition (PPI) is a compelling endophenotype (biological markers) for mental disorders including schizophrenia. In a previous study, we identified Fabp7, a fatty acid binding protein 7 as...