Hair loss and defective T- and B-cell function in mice lacking ORAI1 (2008)
Gwack, Yousang, Srikanth, Sonal, Oh-Hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption...
Suppression of thymic development by the dominant-negative form of Gads (2001)
Kikuchi, Kazu, Kawasaki, Yoshitada, Ishii, Naoto, Sasaki, Yoshiteru, Asao, Hironobu, Takeshita, Toshikazu, ...
Gads, a hematopoietic-lineage-specific Grb2 family member, is involved in the signaling mediated by the TCR through its interactions with SLP-76 and LAT. Here, we generated transgenic mice expressing...
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
Miura, Shigeto, Takeshita, Toshikazu, Asao, Hironobu, Kimura, Yutaka, Murata, Kazuko, Sasaki, Yoshiteru, ...
Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor β (TGF-β) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are...
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
Miura, Shigeto, Takeshita, Toshikazu, Asao, Hironobu, Kimura, Yutaka, Murata, Kazuko, Sasaki, Yoshiteru, ...
Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor β (TGF-β) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are...
Aberrant activation of integrin α4β7 suppresses lymphocyte migration to the gut
Park, Eun Jeong, Mora, J. Rodrigo, Carman, Christopher V., Chen, JianFeng, Sasaki, Yoshiteru, Cheng, Guiying, ...
Integrin adhesion molecules mediate lymphocyte migration and homing to normal and inflamed tissues. While the ligand-binding activity of integrins is known to be modulated by conformational changes,...
Waisman, Ari, Kraus, Manfred, Seagal, Jane, Ghosh, Snigdha, Melamed, Doron, Song, Jian, ...
We describe a mouse strain in which B cell development relies either on the expression of membrane-bound immunoglobulin (Ig) γ1 or μ heavy chains. Progenitor cells expressing γ1 chains from the...
Asada, Hiroshi, Ishii, Naoto, Sasaki, Yoshiteru, Endo, Kazuhiro, Kasai, Hirotake, Tanaka, Nobuyuki, ...
We molecularly cloned a new Grb2 family member, named Grf40, containing the common SH3-SH2-SH3 motif. Expression of Grf40 is predominant in hematopoietic cells, particularly T cells. Grf40 binds to...
Sasaki, Yoshiteru, Calado, Dinis P., Derudder, Emmanuel, Zhang, Baochun, Shimizu, Yuri, Mackay, Fabienne, ...
BAFF-R-dependent activation of the alternative NF-κB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are...
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells
Otipoby, Kevin L., Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Patke, Alina, Gareus, Ralph, Pasparakis, Manolis, ...
B cell activating factor (BAFF) signals through BAFF-R to promote mature B cell survival. Recent analyses of BAFF-induced signaling revealed direct association between augmented B cell metabolic...
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1▿ †
Gwack, Yousang, Srikanth, Sonal, Oh-hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca2+ release-activated Ca2+ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of...
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development
Müller, Martin R., Sasaki, Yoshiteru, Stevanovic, Irena, Lamperti, Edward D., Ghosh, Srimoyee, Sharma, Sonia, ...
NFAT transcription factors are highly phosphorylated proteins residing in the cytoplasm of resting cells. Upon dephosphorylation by the phosphatase calcineurin, NFAT proteins translocate to the...