Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis (2009)
Yoshimura, Takeru, Sonoda, Koh-Hei, Ohguro, Nobuyuki, Ohsugi, Yoshiyuki, Ishibashi, Tatsuro, Cua, Daniel J., ...
Objectives. Human endogenous uveitis is one of the sight-threatening diseases associated with variety of systemic disorders, such as Behcet's disease and sarcoidosis. Recently, biosynthesized...
Taetle, Raymond, Santos, Betty Dos, Ohsugi, Yoshiyuki, Koihihara, Yasuo, Yamada, Yoshiki, Messner, Hans, ...
Background: Although passive serotherapy for cancer with monoclonal antibodies is an attractive concept, it has unfortunately had limited efficacy in clinical trials. An alternative approach to...
Purification and Characterization of Soluble Human IL-6 Receptor Expressed in CHO Cells (1990)
Yasukawa, Kiyoshi, Saito, Takashi, Fukunaga, Takeshi, Sekimori, Yasuo, Koishihara, Yasuo, Fukui, Hiroyasu, ...
An immunosorbent assay system to detect genetically engineered IL-6 receptor (IL-6R) was established, whereby soluble IL-6 receptor (sEL-6R) was detected in the culture medium when sIL-6R cDNA was...
Immunobiology of Germfree Mice Infected with Nocardia asteroides
Beaman, Blaine L., Gershwin, M. Eric, Scates, Steven S., Ohsugi, Yoshiyuki
Nocardia asteroides GUH-2 was administered either intranasally or by intravenous inoculation into (i) conventionally grown, (ii) germfree, and (iii) lipopolysaccharide-treated germfree NIH:S mice....
Immunobiology of Germfree Mice Infected with Nocardia asteroides
Beaman, Blaine L., Gershwin, M. Eric, Scates, Steven S., Ohsugi, Yoshiyuki
Nocardia asteroides GUH-2 was administered either intranasally or by intravenous inoculation into (i) conventionally grown, (ii) germfree, and (iii) lipopolysaccharide-treated germfree NIH:S mice....
Izumi-Nagai, Kanako, Nagai, Norihiro, Ozawa, Yoko, Mihara, Masahiko, Ohsugi, Yoshiyuki, Kurihara, Toshihide, ...
Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with...
Serada, Satoshi, Fujimoto, Minoru, Mihara, Masahiko, Koike, Nobuo, Ohsugi, Yoshiyuki, Nomura, Shintaro, ...
The development of Th17 cells is a key event in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS). Previous studies have...