Hair loss and defective T- and B-cell function in mice lacking ORAI1 (2008)
Gwack, Yousang, Srikanth, Sonal, Oh-Hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption...
Gwack, Yousang, Yoo, Hyouna, Song, Inyoung, Choe, Joonho, Han, Jang H.
Hepatitis G virus (HGV) nonstructural protein 3 (NS3) contains amino acid sequence motifs typical of ATPase and RNA helicase proteins. In order to examine the RNA helicase activity of the HGV NS3...
Park, Junsoo, Seo, Taegun, Hwang, Seungmin, Lee, Daeyoup, Gwack, Yousang, Choe, Joonho
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that...
Gwack, Yousang, Hwang, Seungmin, Byun, Hyewon, Lim, Chunghun, Kim, Jin Woo, Choi, Eui-Ju, ...
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here...
Hwang, Seungmin, Gwack, Yousang, Byun, Hyewon, Lim, Chunghun, Choe, Joonho
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame K8 encodes a basic region-leucine zipper protein of 237 amino acids that homodimerizes with its bZIP domain. KSHV K8 shows...
Gwack, Yousang, Byun, Hyewon, Hwang, Seungmin, Lim, Chunghun, Choe, Joonho
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator, which binds to the KSHV promoter and stimulates the transcription of viral...
Lim, Chunghun, Sohn, Hekwang, Lee, Daeyoup, Gwack, Yousang, Choe, Joonho
Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the maintenance of the viral genome during latent infection. LANA1 colocalizes with...
Gwack, Yousang, Baek, Hwa Jin, Nakamura, Hiroyuki, Lee, Sun Hwa, Meisterernst, Michael, Roeder, Robert G., ...
An important step in the herpesvirus life cycle is the switch from latency to lytic reactivation. The RTA transcription activator of Kaposi's sarcoma-associated herpesvirus (KSHV) acts as a molecular...
Nakamura, Hiroyuki, Lu, Michael, Gwack, Yousang, Souvlis, John, Zeichner, Steven L., Jung, Jae U.
An important step in the herpesvirus life cycle is the switch from latency to lytic reactivation. In order to study the life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV), we developed a...
Gwack, Yousang, Nakamura, Hiroyuki, Lee, Sun Hwa, Souvlis, John, Yustein, Jason T., Gygi, Steve, ...
The replication and transcription activator (RTA) of gamma-2 herpesvirus is sufficient to drive the entire virus lytic cycle. Hence, the control of RTA activity should play an important role in the...
Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein
Lee, Sun-Hwa, Chung, Young-Hwa, Cho, Nam-Hyuk, Gwack, Yousang, Feng, Pinghui, Jung, Jae U.
Because of its central regulatory role, T-cell receptor (TCR) signal transduction is a common target of viruses. We report here the identification of a small signaling protein, ORF5, of the...
Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA
Chang, Heesoon, Gwack, Yousang, Kingston, Dior, Souvlis, John, Liang, Xiaozhen, Means, Robert E., ...
Epstein-Barr virus (EBV) EBNA2 and Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) are recruited to their responsive elements through interaction with a...
Gwack, Yousang, Yoo, Hyouna, Song, Inyoung, Choe, Joonho, Han, Jang H.
Hepatitis G virus (HGV) nonstructural protein 3 (NS3) contains amino acid sequence motifs typical of ATPase and RNA helicase proteins. In order to examine the RNA helicase activity of the HGV NS3...
Park, Junsoo, Seo, Taegun, Hwang, Seungmin, Lee, Daeyoup, Gwack, Yousang, Choe, Joonho
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that...
Gwack, Yousang, Hwang, Seungmin, Byun, Hyewon, Lim, Chunghun, Kim, Jin Woo, Choi, Eui-Ju, ...
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here...
Hwang, Seungmin, Gwack, Yousang, Byun, Hyewon, Lim, Chunghun, Choe, Joonho
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame K8 encodes a basic region-leucine zipper protein of 237 amino acids that homodimerizes with its bZIP domain. KSHV K8 shows...
Gwack, Yousang, Byun, Hyewon, Hwang, Seungmin, Lim, Chunghun, Choe, Joonho
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator, which binds to the KSHV promoter and stimulates the transcription of viral...
Lim, Chunghun, Sohn, Hekwang, Lee, Daeyoup, Gwack, Yousang, Choe, Joonho
Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the maintenance of the viral genome during latent infection. LANA1 colocalizes with...
Gwack, Yousang, Baek, Hwa Jin, Nakamura, Hiroyuki, Lee, Sun Hwa, Meisterernst, Michael, Roeder, Robert G., ...
An important step in the herpesvirus life cycle is the switch from latency to lytic reactivation. The RTA transcription activator of Kaposi's sarcoma-associated herpesvirus (KSHV) acts as a molecular...
Nakamura, Hiroyuki, Lu, Michael, Gwack, Yousang, Souvlis, John, Zeichner, Steven L., Jung, Jae U.
An important step in the herpesvirus life cycle is the switch from latency to lytic reactivation. In order to study the life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV), we developed a...
Gwack, Yousang, Nakamura, Hiroyuki, Lee, Sun Hwa, Souvlis, John, Yustein, Jason T., Gygi, Steve, ...
The replication and transcription activator (RTA) of gamma-2 herpesvirus is sufficient to drive the entire virus lytic cycle. Hence, the control of RTA activity should play an important role in the...
Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein
Lee, Sun-Hwa, Chung, Young-Hwa, Cho, Nam-Hyuk, Gwack, Yousang, Feng, Pinghui, Jung, Jae U.
Because of its central regulatory role, T-cell receptor (TCR) signal transduction is a common target of viruses. We report here the identification of a small signaling protein, ORF5, of the...
Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA
Chang, Heesoon, Gwack, Yousang, Kingston, Dior, Souvlis, John, Liang, Xiaozhen, Means, Robert E., ...
Epstein-Barr virus (EBV) EBNA2 and Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) are recruited to their responsive elements through interaction with a...
Barr, Valarie A., Bernot, Kelsie M., Srikanth, Sonal, Gwack, Yousang, Balagopalan, Lakshmi, Regan, Carole K., ...
The proteins STIM1 and Orai1 are the long sought components of the store-operated channels required in T-cell activation. However, little is known about the interaction of these proteins in T-cells...
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1▿ †
Gwack, Yousang, Srikanth, Sonal, Oh-hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca2+ release-activated Ca2+ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of...
Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68
E, Xiaofei, Hwang, Seungmin, Oh, Soohwan, Lee, Jong-Soo, Jeong, Joseph H., Gwack, Yousang, ...
γ-herpesviruses (γHVs) have developed an interaction with their hosts wherein they establish a life-long persistent infection and are associated with the onset of various malignancies. One critical...