Yozo Ohnishi

A second generation human haplotype map of over 3.1 million SNPs (2007)

Frazer, Kelly A., Ballinger, Dennis G., Cox, David R., Hinds, David A., Stuve, Laura L., Gibbs, Richard A., ...

We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...

Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction (2007)

Hata, Jun, Matsuda, Koichi, Ninomiya, Toshiharu, Yonemoto, Koji, Matsushita, Tomonaga, Ohnishi, Yozo, ...

Brain infarction is one of the common causes of death and also a major cause of severe disability. To identify a gene(s) susceptible to brain infarction, we performed a large-scale association study...

Accurate automated clustering of two-dimensional data for single-nucleotide polymorphism genotyping by a combination of clustering methods: evaluation by large-scale real data (2007)

Takitoh, Shuichi, Fujii, Shogo, Mase, Yoichi, Takasaki, Junichi, Yamazaki, Toshimasa, Ohnishi, Yozo, ...

Motivation: The Invader assay is a fluorescence-based high-throughput genotyping technology. If the output data from the Invader assay were classified automatically, then genotypes for individuals...

Functional SNP in a Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction (2007)

Hata, Jun, Matsuda, Koichi, Ninomiya, Toshiharu, Yonemoto, Koji, Matsushita, Tomonaga, Ohnishi, Yozo, ...

Brain infarction is one of the common causes of death and also a major cause of severe disability. To identify a gene(s) susceptible to brain infarction, we performed a large-scale association study...

Linkage disequilibrium of evolutionarily conserved regions in the human genome (2006)

Kato, Mamoru, Sekine, Akihiro, Ohnishi, Yozo, Johnson, Todd A, Tanaka, Toshihiro, Nakamura, Yusuke, ...

Abstract Background The strong linkage disequilibrium (LD) recently found in genic or exonic regions of the human genome demonstrated that LD can be increased by evolutionary mechanisms that select...

BioMed Central (2006)

Bmc Genomics, Mamoru Kato, Akihiro Sekine, Yozo Ohnishi, Toshihiro Tanaka, Yusuke Nakamura, ...

Research article Linkage disequilibrium of evolutionarily conserved regions in the human genome

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities (2005)

Kochi, Yuta, Yamada, Ryo, Suzuki, Akari, Harley, John B., Shirasawa, Senji, Sawada, Tetsuji, ...

http://www.nature.com/ng/journal/v37/n5/full/ng1540.html

Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome (2004)

Tsunoda, Tatsuhiko, Lathrop, G. Mark, Sekine, Akihiro, Yamada, Ryo, Takahashi, Atsushi, Ohnishi, Yozo, ...

A principal goal in human genetics is to provide the tools necessary to enable genome-wide association studies. Extensive information on the distribution of gene-based single-nucleotide polymorphisms...

Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome (2004)

Tsunoda, Tatsuhiko, Lathrop, G. Mark, Sekine, Akihiro, Yamada, Ryo, Takahashi, Atsushi, Ohnishi, Yozo, ...

A principal goal in human genetics is to provide the tools necessary to enable genome-wide association studies. Extensive information on the distribution of gene-based single-nucleotide polymorphisms...

Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome (2004)

Tsunoda, Tatsuhiko, Lathrop, G. Mark, Sekine, Akihiro, Yamada, Ryo, Takahashi, Atsushi, Ohnishi, Yozo, ...

A principal goal in human genetics is to provide the tools necessary to enable genome-wide association studies. Extensive information on the distribution of gene-based single-nucleotide polymorphisms...

Association between a Single-Nucleotide Polymorphism in the Promoter of the Human Interleukin-3 Gene and Rheumatoid Arthritis in Japanese Patients, and Maximum-Likelihood Estimation of Combinatorial Effect That Two Genetic Loci Have on Susceptibility to the Disease

Yamada, Ryo, Tanaka, Toshihiro, Unoki, Motoko, Nagai, Tatsuo, Sawada, Tetsuji, Ohnishi, Yozo, ...

Genetic variants of interleukin-3 (IL-3), a well-studied cytokine, may have a role in the pathophysiology of rheumatoid arthritis (RA); but reports on this association sometimes conflict. A...

A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities

Kochi, Yuta, Yamada, Ryo, Suzuki, Akari, Harley, John B., Shirasawa, Senji, Sawada, Tetsuji, ...

Rheumatoid arthritis (RA) is a common autoimmune disease with a complex genetic etiology. Herein we identify a single-nucleotide polymorphism (SNP) in the promoter region of FcRH3, a member of the Fc...

Association between Single-Nucleotide Polymorphisms in Selectin Genes and Immunoglobulin A Nephropathy

Takei, Takashi, Iida, Aritoshi, Nitta, Kosaku, Tanaka, Toshihiro, Ohnishi, Yozo, Yamada, Ryo, ...

Although intensive efforts have been undertaken to elucidate the genetic background of immunoglobulin A nephropathy (IgAN), genetic factors associated with the pathogenesis of this disease are still...

Association between a Single-Nucleotide Polymorphism in the Promoter of the Human Interleukin-3 Gene and Rheumatoid Arthritis in Japanese Patients, and Maximum-Likelihood Estimation of Combinatorial Effect That Two Genetic Loci Have on Susceptibility to the Disease

Yamada, Ryo, Tanaka, Toshihiro, Unoki, Motoko, Nagai, Tatsuo, Sawada, Tetsuji, Ohnishi, Yozo, ...

Genetic variants of interleukin-3 (IL-3), a well-studied cytokine, may have a role in the pathophysiology of rheumatoid arthritis (RA); but reports on this association sometimes conflict. A...

Linkage disequilibrium of evolutionarily conserved regions in the human genome

Kato, Mamoru, Sekine, Akihiro, Ohnishi, Yozo, Johnson, Todd A, Tanaka, Toshihiro, Nakamura, Yusuke, ...