Yuan-Xiang Tao

Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain (2008)

Park, Jang-Su, Yaster, Myron, Guan, Xiaowei, Xu, Ji-Tian, Shih, Ming-Hung, Guan, Yun, ...

Abstract Spinal cord α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate acute spinal processing of nociceptive and non-nociceptive information, but whether and how their...

Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein (2008)

Liaw, Wen-Jinn, Zhu, Xu-Guang, Yaster, Myron, Johns, Roger A, Gauda, Estelle B, Tao, Yuan-Xiang

Abstract Postsynaptic density (PSD)-93, a neuronal scaffolding protein, binds to and clusters N -methyl-D-aspartate receptor (NMDAR) subunits NR2A and NR2B at cellular membranes in vitro . However,...

Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice (2007)

Guan, Yun, Yaster, Myron, Raja, Srinivasa N, Tao, Yuan-Xiang

Abstract Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in neuronal tissues and contributes to the spinal central sensitization in inflammatory pain. However, the...

Inward currents induced by ischemia in rat spinal cord dorsal horn neurons (2007)

Chen, Meng, Tao, Yuan-Xiang, Gu, Jianguo G

Abstract Hypoxia and ischemia occur in the spinal cord when blood vessels of the spinal cord are compressed under pathological conditions such as spinal stenosis, tumors, and traumatic spinal injury....

Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states (2005)

Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L

Abstract Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...

Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states

Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L

Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...

Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states

Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L

Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...

Inward currents induced by ischemia in rat spinal cord dorsal horn neurons

Chen, Meng, Tao, Yuan-Xiang, Gu, Jianguo G

Hypoxia and ischemia occur in the spinal cord when blood vessels of the spinal cord are compressed under pathological conditions such as spinal stenosis, tumors, and traumatic spinal injury. Here by...

Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice

Guan, Yun, Yaster, Myron, Raja, Srinivasa N, Tao, Yuan-Xiang

Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in neuronal tissues and contributes to the spinal central sensitization in inflammatory pain. However, the role of...

PDZ Domains at Excitatory Synapses: Potential Molecular Targets for Persistent Pain Treatment

Tao, Yuan-Xiang, Johns, Roger A

Persistent pain, a common clinical condition, could be caused by inflammation, tissue injury secondary to trauma or surgery, and nerve injuries. It is often inadequately controlled by current...

Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein

Liaw, Wen-Jinn, Zhu, Xu-Guang, Yaster, Myron, Johns, Roger A, Gauda, Estelle B, Tao, Yuan-Xiang

Postsynaptic density (PSD)-93, a neuronal scaffolding protein, binds to and clusters N-methyl-D-aspartate receptor (NMDAR) subunits NR2A and NR2B at cellular membranes in vitro. However, the roles of...

Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain

Park, Jang-Su, Yaster, Myron, Guan, Xiaowei, Xu, Ji-Tian, Shih, Ming-Hung, Guan, Yun, ...

Spinal cord α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate acute spinal processing of nociceptive and non-nociceptive information, but whether and how their...