Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophilaeye (2009)
Wu, Yue, Zhuang, Yuan, Han, Min, Xu, Tian, Deng, Kejing
Abstract Background Programmed cell death, or apoptosis, is a fundamental physiological process during normal development or in pathological conditions. The activation of apoptosis can be elicited by...
A tamoxifen inducible knock-in allele for investigation of E2A function (2009)
Jones, Mary E, Kondo, Motonari, Zhuang, Yuan
Abstract Background E-proteins are transcription factors important for the development of a variety of cell types, including neural, muscle and lymphocytes of the immune system. E2A, the best...
Sun, Ling V., Jin, Ke, Liu, Yiming, Yang, Wenwei, Xie, Xing, Ye, Lin, ...
DNA transposon piggyBac (PB) is a newly established mutagen for large-scale mutagenesis in mice. We have designed and implemented an integrated database system called PBmice (PB Mutagenesis...
ADAM10 is essential for proteolytic activation of Notch during thymocyte development (2008)
Tian, Lei, Wu, Xiaohui, Chi, Congwu, Han, Min, Xu, Tian, Zhuang, Yuan
Notch signaling pathway has been shown to play essential roles in T lymphocyte development. Activation of Notch requires a sequential proteolytic cleavage, which converts Notch from the full-length...
PBmice: an integrated database system of (2007)
Ling V. Sun, Ke Jin, Yiming Liu, Wenwei Yang, Xing Xie, Lin Ye, ...
doi:10.1093/nar/gkm790
Development of a web-based laboratory for control experiments on a coupled tank apparatus (2001)
C. C. Ko, Senior Member, Ben M. Chen, Jianping Chen, Yuan Zhuang, Kay Chen Tan
Abstract—The Internet provides a new environment for developing a variety of applications for educational and research purposes. This paper presents the implementation of a web-based laboratory...
A Web-Based Virtual Laboratory on a Frequency Modulation Experiment (2001)
Chi Chung Ko, Senior Member, Ben M. Chen, Shaoyan Hu, Vikram Ramakrishnan, Chang Dong Cheng, ...
Abstract—With the rapid proliferation of Internet technologies, accessing and operating engineering instruments remotely anytime anywhere is fast becoming a reality. This paper presents a new...
Thesis (M.S.)--Brigham Young University. Dept. of Computer Science, 1999.
In this thesis, we investigate full-wave hybrid Conjugate Gradient-Fast Fourier Transform (CG-FFT) methods for analyzing microstrip arrays. In particular, we investigate spectral preconditioning with...
Thesis (Ph. D.)--McMaster University, 1996.
Datto, Michael B., Frederick, Joshua P., Pan, Lihua, Borton, Anita J., Zhuang, Yuan, Wang, Xiao-Fan
The Smads are a family of nine related proteins which function as signaling intermediates for the transforming growth factor β (TGF-β) superfamily of ligands. To discern the in vivo functions of...
Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene
Pan, Lihua, Sato, Shinichi, Frederick, Joshua P., Sun, Xiao-Hong, Zhuang, Yuan
B-lymphocyte activation and proliferation induced by the B-cell receptor (BCR) signals are important steps in the initiation of humoral immune responses. How the BCR signals are translated by nuclear...
Barndt, Robert J., Dai, Meifang, Zhuang, Yuan
Lymphocyte development and differentiation are regulated by the basic helix-loop-helix (bHLH) transcription factors encoded by the E2A and HEB genes. These bHLH proteins bind to E-box enhancers in...
Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA
Zhuang, Yuan, Barndt, Robert J., Pan, Lihua, Kelley, Robert, Dai, Meifang
The mammalian E2A, HEB, and E2-2 genes encode a unique class of basic helix-loop-helix (bHLH) transcription factors that are evolutionarily conserved and essential for embryonic and postnatal...
Guo, Zijian, Clydesdale, Gavin, Cheng, Jinke, Kim, Kihwan, Gan, Lin, McConkey, David J., ...
MEKK2 is a member of the mitogen-activated protein kinase (MAPK) kinase kinase gene family involved in regulating multiple MAPK signaling pathways. To elucidate the in vivo function of MEKK2, we...
Greenbaum, Stephen, Zhuang, Yuan
The transcription factors encoded by the E2A gene are known to be essential for B lymphocyte development, and ectopic expression or gene inactivation studies have revealed several potential...
Lazorchak, Adam S., Schlissel, Mark S., Zhuang, Yuan
The immunoglobulin kappa light chain (Igκ) locus is regulated in a lineage- and stage-specific manner during B-cell development. The highly restricted timing of V to J gene recombination at the...
Datto, Michael B., Frederick, Joshua P., Pan, Lihua, Borton, Anita J., Zhuang, Yuan, Wang, Xiao-Fan
The Smads are a family of nine related proteins which function as signaling intermediates for the transforming growth factor β (TGF-β) superfamily of ligands. To discern the in vivo functions of...
Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene
Pan, Lihua, Sato, Shinichi, Frederick, Joshua P., Sun, Xiao-Hong, Zhuang, Yuan
B-lymphocyte activation and proliferation induced by the B-cell receptor (BCR) signals are important steps in the initiation of humoral immune responses. How the BCR signals are translated by nuclear...
Barndt, Robert J., Dai, Meifang, Zhuang, Yuan
Lymphocyte development and differentiation are regulated by the basic helix-loop-helix (bHLH) transcription factors encoded by the E2A and HEB genes. These bHLH proteins bind to E-box enhancers in...
Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA
Zhuang, Yuan, Barndt, Robert J., Pan, Lihua, Kelley, Robert, Dai, Meifang
The mammalian E2A, HEB, and E2-2 genes encode a unique class of basic helix-loop-helix (bHLH) transcription factors that are evolutionarily conserved and essential for embryonic and postnatal...
Guo, Zijian, Clydesdale, Gavin, Cheng, Jinke, Kim, Kihwan, Gan, Lin, McConkey, David J., ...
MEKK2 is a member of the mitogen-activated protein kinase (MAPK) kinase kinase gene family involved in regulating multiple MAPK signaling pathways. To elucidate the in vivo function of MEKK2, we...
Greenbaum, Stephen, Zhuang, Yuan
The transcription factors encoded by the E2A gene are known to be essential for B lymphocyte development, and ectopic expression or gene inactivation studies have revealed several potential...
Lazorchak, Adam S., Schlissel, Mark S., Zhuang, Yuan
The immunoglobulin kappa light chain (Igκ) locus is regulated in a lineage- and stage-specific manner during B-cell development. The highly restricted timing of V to J gene recombination at the...
Pan, Lihua, Bradney, Curtis, Zheng, Biao, Zhuang, Yuan
E2A has been shown to be an important transcription factor downstream of the T-cell receptor (TCR) signal during T-cell development. The TCR signal is known to elicit different cellular responses at...
Sun, Ling V., Jin, Ke, Liu, Yiming, Yang, Wenwei, Xie, Xing, Ye, Lin, ...
DNA transposon piggyBac (PB) is a newly established mutagen for large-scale mutagenesis in mice. We have designed and implemented an integrated database system called PBmice (PB Mutagenesis...
Germline transcription from T-cell receptor Vβ gene is uncoupled from allelic exclusion
Jia, Jingquan, Kondo, Motonari, Zhuang, Yuan
Allelic exclusion operates in B and T lymphocytes to ensure clonal expression of antigen receptors after V(D)J recombination. Germline transcription, which proceeds V(D)J recombination, has been...
B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice
Hayakawa, Ikuko, Tedder, Thomas F, Zhuang, Yuan
Sjögren's syndrome is an autoimmune disease in which immune cells chronically attack the lachrymal and salivary glands. The Id3 knockout mouse is a newly established animal model for primary...
A mitotic recombination system for mouse chromosome 17
Sun, Lei, Wu, Xiaohui, Han, Min, Xu, Tian, Zhuang, Yuan
Mitotic recombination between homologous chromosomes is a genetic technique for mosaic analysis in model organisms. The general application of this technique in the mouse depends on establishment of...