Huang, Jie, Dattilo, Lisa K, Kaartinen, Vesa, Mishina, Yuji, Deng, Chu-Xia, ...
BMPs play multiple roles in development and BMP signaling is essential for lens formation. However, the mechanisms by which BMP receptors function in vertebrate development are incompletely...
Dattilo, Lisa K, Rajagopal, Ramya, Liu, Ying, Kaartinen, Vesa, Mishina, Yuji, ...
There are conflicting reports about whether BMP signaling is required for eyelid closure during fetal development. This question was addressed using mice deficient in BMP or TGF beta signaling in...
Morley, Gregory E, Vance, Kendra M, Emile, Lorin, ...
Endocardial cushions are precursors of mature atrioventricular (AV) valves. Their formation is induced by signaling molecules originating from the AV myocardium, including bone morphogenetic proteins...
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage (2004)
Ryan B. Rountree, Michael Schoor, Hao Chen, Melissa E. Marks, Vincent Harley, Yuji Mishina, ...
Through genetic manipulation, these authors have reduced signaling by bone morphogenetic factors in joint regions, and created a valuable model for the study of arthritis.
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage (2004)
Ryan B. Rountree, Michael Schoor, Hao Chen, Melissa E. Marks, Vincent Harley, Yuji Mishina, ...
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. The molecular mechanisms that create and maintain...
Suzuki, Kentaro, Bachiller, Daniel, YiPing, P. Chen, Kamikawa, Mami, Ogi, Hidenao, Haraguchi, Ryouma, ...
Extra-corporal fertilization depends on the formation of copulatory organs: the external genitalia. Coordinated growth and differentiation of the genital tubercle (GT), an embryonic anlage of...
Soshnikova, Natalia, Zechner, Dietmar, Huelsken, Joerg, Mishina, Yuji, Behringer, Richard R., Taketo, Makoto M., ...
By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and...
Mishina, Yuji, Hanks, Mark C, ...
Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGFbeta) superfamily, are persistently expressed during cardiac development, yet mice lacking type II...
Gaussin, Vinciane, Van De Putte, Tom, Mishina, Yuji, Hanks, Mark C., Zwijsen, An, Huylebroeck, Danny, ...
Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGFβ) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or...
Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism
Takeda, Haruko, Takami, Marika, Oguni, Tomoko, Tsuji, Takehito, Yoneda, Kazuhiro, Sato, Hiroaki, ...
Chondrodysplastic dwarfism in Japanese brown cattle is an autosomal recessive disorder characterized by short limbs. Previously, we mapped the locus responsible for the disease on the distal end of...
Soshnikova, Natalia, Zechner, Dietmar, Huelsken, Joerg, Mishina, Yuji, Behringer, Richard R., Taketo, Makoto M., ...
By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and...
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Oh, Hidemasa, Bradfute, Steven B., Gallardo, Teresa D., Nakamura, Teruya, Gaussin, Vinciane, Mishina, Yuji, ...
Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the...
Qi, Xiaoxia, Li, Teng-Guo, Hao, Jing, Hu, Jie, Wang, Jing, Simmons, Holly, ...
The fate of pluripotent stem cells is tightly controlled during early embryonic development. Both the derivation and the maintenance of embryonic stem cells (ES cells) in vitro depend on feeder...
Stumpo, Deborah J., Byrd, Noah A., Phillips, Ruth S., Ghosh, Sanjukta, Maronpot, Robert R., Castranio, Trisha, ...
The mouse gene Zfp36L1 encodes zinc finger protein 36-like 1 (Zfp36L1), a member of the tristetraprolin (TTP) family of tandem CCCH finger proteins. TTP can bind to AU-rich elements within the...
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage
Rountree, Ryan B, Schoor, Michael, Chen, Hao, Marks, Melissa E, Harley, Vincent, Mishina, Yuji, ...
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. The molecular mechanisms that create and maintain...
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
Yoon, Byeong S., Ovchinnikov, Dmitry A., Yoshii, Isaac, Mishina, Yuji, Behringer, Richard R., Lyons, Karen M.
Previous studies have demonstrated the ability of bone morphogenetic proteins (BMPs) to promote chondrogenic differentiation in vitro. However, the in vivo role of BMP signaling during chondrogenesis...
Fukuda, Tomokazu, Mishina, Yuji, Walker, Michael P., DiAugustine, Richard P.
Aurora A is a mitotic kinase that localizes to centrosomes. Expression of this protein is normally limited to the mitotic stage (G2-M) of the cell cycle, whereas human cancer cells frequently exhibit...
Gaussin, Vinciane, Van De Putte, Tom, Mishina, Yuji, Hanks, Mark C., Zwijsen, An, Huylebroeck, Danny, ...
Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGFβ) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or...
Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism
Takeda, Haruko, Takami, Marika, Oguni, Tomoko, Tsuji, Takehito, Yoneda, Kazuhiro, Sato, Hiroaki, ...
Chondrodysplastic dwarfism in Japanese brown cattle is an autosomal recessive disorder characterized by short limbs. Previously, we mapped the locus responsible for the disease on the distal end of...
Soshnikova, Natalia, Zechner, Dietmar, Huelsken, Joerg, Mishina, Yuji, Behringer, Richard R., Taketo, Makoto M., ...
By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and...
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Oh, Hidemasa, Bradfute, Steven B., Gallardo, Teresa D., Nakamura, Teruya, Gaussin, Vinciane, Mishina, Yuji, ...
Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the...
Qi, Xiaoxia, Li, Teng-Guo, Hao, Jing, Hu, Jie, Wang, Jing, Simmons, Holly, ...
The fate of pluripotent stem cells is tightly controlled during early embryonic development. Both the derivation and the maintenance of embryonic stem cells (ES cells) in vitro depend on feeder...
Stumpo, Deborah J., Byrd, Noah A., Phillips, Ruth S., Ghosh, Sanjukta, Maronpot, Robert R., Castranio, Trisha, ...
The mouse gene Zfp36L1 encodes zinc finger protein 36-like 1 (Zfp36L1), a member of the tristetraprolin (TTP) family of tandem CCCH finger proteins. TTP can bind to AU-rich elements within the...
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage
Rountree, Ryan B, Schoor, Michael, Chen, Hao, Marks, Melissa E, Harley, Vincent, Mishina, Yuji, ...
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. The molecular mechanisms that create and maintain...
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
Yoon, Byeong S., Ovchinnikov, Dmitry A., Yoshii, Isaac, Mishina, Yuji, Behringer, Richard R., Lyons, Karen M.
Previous studies have demonstrated the ability of bone morphogenetic proteins (BMPs) to promote chondrogenic differentiation in vitro. However, the in vivo role of BMP signaling during chondrogenesis...
Fukuda, Tomokazu, Mishina, Yuji, Walker, Michael P., DiAugustine, Richard P.
Aurora A is a mitotic kinase that localizes to centrosomes. Expression of this protein is normally limited to the mitotic stage (G2-M) of the cell cycle, whereas human cancer cells frequently exhibit...
Sun, Jianping, Chen, Hui, Chen, Cheng, Whitsett, Jeffrey A., Mishina, Yuji, Bringas, Pablo, ...
Bone morphogenetic proteins (BMPs) play important roles in regulating lung development and function although the endogenous regulatory effects of BMP signaling are still controversial. We found that...
BMP Receptor ALK3 Controls Collecting System Development
Hartwig, Sunny, Bridgewater, Darren, Di Giovanni, Valeria, Cain, Jason, Mishina, Yuji, Rosenblum, Norman D.
The molecular signals that regulate growth and branching of the ureteric bud during formation of the renal collecting system are largely undefined. Members of the bone morphogenetic protein (BMP)...
Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells▿ †
Greer Card, Deborah A., Hebbar, Pratibha B., Li, Leping, Trotter, Kevin W., Komatsu, Yoshihiro, Mishina, Yuji, ...
Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis and for the maintenance of embryonic stem cell (ESC) identity. Functional mechanisms contributing to...
Inagaki, Maiko, Omori, Emily, Kim, Jae-Young, Komatsu, Yoshihiro, Scott, Greg, Ray, Manas K., ...
TAK1 kinase is an indispensable intermediate in several cytokine signaling pathways including tumor necrosis factor, interleukin-1, and transforming growth factor-β signaling pathways. TAK1 also...