Identification of a signature motif in target mRNAs of RNA-binding protein AUF1 (2009)
Mazan-Mamczarz, Krystyna, Kuwano, Yuki, Zhan, Ming, White, Elizabeth J., Martindale, Jennifer L., Lal, Ashish, ...
The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1-associated mRNAs by...
HuR recruits let-7/RISC to repress c-Myc expression (2009)
Kim, Hyeon Ho, Kuwano, Yuki, Srikantan, Subramanya, Lee, Eun Kyung, Martindale, Jennifer L., Gorospe, Myriam
RNA-binding proteins (RBPs) and microRNAs (miRNAs) are potent post-transcriptional regulators of gene expression. Here, we show that the RBP HuR reduced c-Myc expression by associating with the c-Myc...
Elucidation of a C-Rich Signature Motif in Target mRNAs of RNA-Binding Protein TIAR▿ †
Kim, Henry S., Kuwano, Yuki, Zhan, Ming, Pullmann, Rudolf, Mazan-Mamczarz, Krystyna, Li, Huai, ...
The RNA-binding protein TIAR (related to TIA-1 [T-cell-restricted intracellular antigen 1]) was shown to associate with subsets of mRNAs bearing U-rich sequences in their 3′ untranslated regions....
p16INK4a Translation Suppressed by miR-24
Lal, Ashish, Kim, Hyeon Ho, Abdelmohsen, Kotb, Kuwano, Yuki, Pullmann, Rudolf, Srikantan, Subramanya, ...
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α▿ †
Galbán, Stefanie, Kuwano, Yuki, Pullmann, Rudolf, Martindale, Jennifer L., Kim, Hyeon Ho, Lal, Ashish, ...
The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa cells...
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90▿ †
Kuwano, Yuki, Kim, Hyeon Ho, Abdelmohsen, Kotb, Pullmann, Rudolf, Martindale, Jennifer L., Yang, Xiaoling, ...
The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated kinase (ERK), c-Jun...
Identification of a signature motif in target mRNAs of RNA-binding protein AUF1
Mazan-Mamczarz, Krystyna, Kuwano, Yuki, Zhan, Ming, White, Elizabeth J., Martindale, Jennifer L., Lal, Ashish, ...
The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1-associated mRNAs by...
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam
Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The RBP HuR can stabilize and...
Kuwano, Yuki, Rabinovic, Ariel, Srikantan, Subramanya, Gorospe, Myriam, Demple, Bruce
We previously observed that nitric oxide (NO) exposure increases the stability of mRNAs encoding heme oxygenase 1 (HO-1) and TIEG-1 in human and mouse fibroblasts. Here, we have used microarrays to...