Kamiya, Hiroyuki, Suzuki, Akihiro, Yamaguchi, Yuki, Handa, Hiroshi, Harashima, Hideyoshi
Oxidized RNA precursors formed in the nucleotide pool may be incorporated into RNA. In this study, the incorporation of 8-hydroxyguanosine 5'-triphosphate (8-OH-GTP; 8-oxo-7,8-dihydroguanosine...
Kuramori, Chikanori, Hase, Yasuyoshi, Hoshikawa, Koichi, Watanabe, Keiko, Nishi, Takeyuki, Hishiki, Takako, ...
Phthalate esters are commonly used plasticizers; however, some are suspected to cause reproductive toxicity. Administration of high doses of di-(2-ethylhexyl) phthalate (DEHP) induces germ cell death...
Ando, Kozue, Hirao, Satoshi, Kabe, Yasuaki, Ogura, Yuji, Sato, Iwao, Yamaguchi, Yuki, ...
APE1/Ref-1 is thought to be a multifunctional protein involved in reduction–oxidation (redox) regulation and base excision DNA repair, and is required for early embryonic development in mice....
Zhu, Wenyan, Wada, Tadashi, Okabe, Sachiko, Taneda, Takuya, Yamaguchi, Yuki, Handa, Hiroshi
The transcription elongation factor 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) regulates RNA polymerase II (RNAPII) processivity by promoting, in concert...
Emotional memories are not all created equal: Evidence for selective memory enhancement (2006)
Anderson, Adam K., Yamaguchi, Yuki, Grabski, Wojtek, Lacka, Dominika
Human brain imaging studies have shown that greater amygdala activation to emotional relative to neutral events leads to enhanced episodic memory. Other studies have shown that fearful faces also...
Kubo, Tomohiro, Wada, Tadashi, Yamaguchi, Yuki, Shimizu, Akira, Handa, Hiroshi
Alternative polyadenylation leads to mRNAs with variable 3′ ends. Since a 3′-untranslated region (3′-UTR) often contains cis elements that impact stability or localization of mRNA or...
Emotional memories are not all created equal: Evidence for selective memory enhancement (2006)
Anderson, Adam K., Yamaguchi, Yuki, Grabski, Wojtek, Lacka, Dominika
Human brain imaging studies have shown that greater amygdala activation to emotional relative to neutral events leads to enhanced episodic memory. Other studies have shown that fearful faces also...
Emotional memories are not all created equal: Evidence for selective memory enhancement (2006)
Anderson, Adam K., Yamaguchi, Yuki, Grabski, Wojtek, Lacka, Dominika
Human brain imaging studies have shown that greater amygdala activation to emotional relative to neutral events leads to enhanced episodic memory. Other studies have shown that fearful faces also...
Molecular characterization of Drosophila NELF (2005)
Wu, Chwen-Huey, Lee, Chanhyo, Fan, Ruopeng, Smith, Meghan J., Yamaguchi, Yuki, Handa, Hiroshi, ...
NELF and DSIF act together to inhibit transcription elongation in vitro, and are implicated in causing promoter proximal pausing on the hsp70 gene in Drosophila. Here, further characterization of...
Azuma, Noriyuki, Tadokoro, Keiko, Asaka, Astuko, Yamada, Masao, Yamaguchi, Yuki, Handa, Hiroshi, ...
The vertebrate retina has an area where visual cells are closely packed for proper vision that is known as a fovea, an area centralis or a visual streak. The molecular mechanism that regulates the...
Azuma, Noriyuki, Tadokoro, Keiko, Asaka, Astuko, Yamada, Masao, Yamaguchi, Yuki, Handa, Hiroshi, ...
The Pax6 gene plays an important role in eye morphogenesis throughout the animal kingdom. The Pax6 gene and its homologue could form ectopic eyes by targeted expression in Drosophila and Xenopus....
Aiyar, Sarah E., Sun, Jian-long, Blair, Ashley L., Moskaluk, Christopher A., Lu, Yun-zhe, Ye, Qi-nong, ...
Estrogen receptor α (ERα) signaling is paramount for normal mammary gland development and function and the repression of breast cancer. ERα function in gene regulation is mediated by a number of...
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila (2003)
Wu, Chwen-Huey, Yamaguchi, Yuki, Benjamin, Lawrence R., Horvat-Gordon, Maria, Washinsky, Jodi, Enerly, Espen, ...
NELF and DSIF collaborate to inhibit elongation by RNA polymerase IIa in extracts from human cells. A multifaceted approach was taken to investigate the potential role of these factors in promoter...
A Rapid Purification Method for Human RNA Polymerase II by Two-Step Affinity Chromatography (2003)
Hasegawa, Jun, Endou, Masaki, Narita, Takashi, Yamada, Tomoko, Yamaguchi, Yuki, Wada, Tadashi, ...
The molecular dissection of transcription mechanisms is greatly facilitated by constructing and manipulating defined transcription systems in vitro. This approach requires highly purified...
Yamaguchi, Yuki, Narita, Takashi, Inukai, Naoto, Wada, Tadashi, Handa, Hiroshi
Suppressor of Ty (SPT) genes were originally identified through a genetic screen for mutations in the yeast Saccharomyces cerevisiae that restore gene expression disrupted by the insertion of the...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins
Kim, Jae B., Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi, Sharp, Phillip A.
The potent transactivator Tat recognizes the transactivation response RNA element (TAR) of human immunodeficiency virus type 1 and stimulates the processivity of elongation of RNA polymerase (Pol) II...
Yamaguchi, Yuki, Inukai, Naoto, Narita, Takashi, Wada, Tadashi, Handa, Hiroshi
Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII)....
Narita, Takashi, Yamaguchi, Yuki, Yano, Keiichi, Sugimoto, Seiji, Chanarat, Sittinan, Wada, Tadashi, ...
The multisubunit transcription elongation factor NELF (for negative elongation factor) acts together with DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF)/human...
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila
Wu, Chwen-Huey, Yamaguchi, Yuki, Benjamin, Lawrence R., Horvat-Gordon, Maria, Washinsky, Jodi, Enerly, Espen, ...
NELF and DSIF collaborate to inhibit elongation by RNA polymerase IIa in extracts from human cells. A multifaceted approach was taken to investigate the potential role of these factors in promoter...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor...
Ainbinder, Elena, Amir-Zilberstein, Liat, Yamaguchi, Yuki, Handa, Hiroshi, Dikstein, Rivka
A20 is an immediate-early NF-κB target gene. Prior to NF-κB stimulation, the A20 promoter is bound by the polymerase II machinery to allow rapid transcription activation. Here we show that the...
Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro
Endoh, Masaki, Zhu, Wenyan, Hasegawa, Jun, Watanabe, Hajime, Kim, Dong-Ki, Aida, Masatoshi, ...
Recent studies have suggested that Spt6 participates in the regulation of transcription by RNA polymerase II (RNAPII). However, its underlying mechanism remains largely unknown. One possibility,...
Oshima, Shigeru, Nakamura, Tetsuya, Namiki, Shin, Okada, Eriko, Tsuchiya, Kiichiro, Okamoto, Ryuichi, ...
Intestinal epithelial cell-derived interleukin (IL)-7 functions as a pleiotropic and nonredundant cytokine in the human intestinal mucosa; however, the molecular basis of its production has remained...
Aiyar, Sarah E., Sun, Jian-long, Blair, Ashley L., Moskaluk, Christopher A., Lu, Yun-zhe, Ye, Qi-nong, ...
Estrogen receptor α (ERα) signaling is paramount for normal mammary gland development and function and the repression of breast cancer. ERα function in gene regulation is mediated by a number of...
Kabe, Yasuaki, Yamada, Joe, Uga, Hitoshi, Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi
Osteoclast differentiation factor (ODF)/receptor activator of NF-κB ligand is essential for inducing the differentiation of mature osteoclasts. We find that nuclear factor Y (NF-Y) binds to the...
Molecular characterization of Drosophila NELF
Wu, Chwen-Huey, Lee, Chanhyo, Fan, Ruopeng, Smith, Meghan J., Yamaguchi, Yuki, Handa, Hiroshi, ...
NELF and DSIF act together to inhibit transcription elongation in vitro, and are implicated in causing promoter proximal pausing on the hsp70 gene in Drosophila. Here, further characterization of...
Aida, Masatoshi, Chen, Yexi, Nakajima, Koichi, Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi
Human 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) negatively regulate transcription elongation by RNA polymerase II...
Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins
Kim, Jae B., Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi, Sharp, Phillip A.
The potent transactivator Tat recognizes the transactivation response RNA element (TAR) of human immunodeficiency virus type 1 and stimulates the processivity of elongation of RNA polymerase (Pol) II...
Yamaguchi, Yuki, Inukai, Naoto, Narita, Takashi, Wada, Tadashi, Handa, Hiroshi
Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII)....
Narita, Takashi, Yamaguchi, Yuki, Yano, Keiichi, Sugimoto, Seiji, Chanarat, Sittinan, Wada, Tadashi, ...
The multisubunit transcription elongation factor NELF (for negative elongation factor) acts together with DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF)/human...
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila
Wu, Chwen-Huey, Yamaguchi, Yuki, Benjamin, Lawrence R., Horvat-Gordon, Maria, Washinsky, Jodi, Enerly, Espen, ...
NELF and DSIF collaborate to inhibit elongation by RNA polymerase IIa in extracts from human cells. A multifaceted approach was taken to investigate the potential role of these factors in promoter...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor...
Ainbinder, Elena, Amir-Zilberstein, Liat, Yamaguchi, Yuki, Handa, Hiroshi, Dikstein, Rivka
A20 is an immediate-early NF-κB target gene. Prior to NF-κB stimulation, the A20 promoter is bound by the polymerase II machinery to allow rapid transcription activation. Here we show that the...
Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro
Endoh, Masaki, Zhu, Wenyan, Hasegawa, Jun, Watanabe, Hajime, Kim, Dong-Ki, Aida, Masatoshi, ...
Recent studies have suggested that Spt6 participates in the regulation of transcription by RNA polymerase II (RNAPII). However, its underlying mechanism remains largely unknown. One possibility,...
Oshima, Shigeru, Nakamura, Tetsuya, Namiki, Shin, Okada, Eriko, Tsuchiya, Kiichiro, Okamoto, Ryuichi, ...
Intestinal epithelial cell-derived interleukin (IL)-7 functions as a pleiotropic and nonredundant cytokine in the human intestinal mucosa; however, the molecular basis of its production has remained...
Aiyar, Sarah E., Sun, Jian-long, Blair, Ashley L., Moskaluk, Christopher A., Lu, Yun-zhe, Ye, Qi-nong, ...
Estrogen receptor α (ERα) signaling is paramount for normal mammary gland development and function and the repression of breast cancer. ERα function in gene regulation is mediated by a number of...
Kabe, Yasuaki, Yamada, Joe, Uga, Hitoshi, Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi
Osteoclast differentiation factor (ODF)/receptor activator of NF-κB ligand is essential for inducing the differentiation of mature osteoclasts. We find that nuclear factor Y (NF-Y) binds to the...
Molecular characterization of Drosophila NELF
Wu, Chwen-Huey, Lee, Chanhyo, Fan, Ruopeng, Smith, Meghan J., Yamaguchi, Yuki, Handa, Hiroshi, ...
NELF and DSIF act together to inhibit transcription elongation in vitro, and are implicated in causing promoter proximal pausing on the hsp70 gene in Drosophila. Here, further characterization of...
Mutations of the PAX6 Gene Detected in Patients with a Variety of Optic-Nerve Malformations
Azuma, Noriyuki, Yamaguchi, Yuki, Handa, Hiroshi, Tadokoro, Keiko, Asaka, Atsuko, Kawase, Eriko, ...
The PAX6 gene is involved in ocular morphogenesis and is expressed in the developing central nervous system and numerous ocular tissues during development. PAX6 mutations have been detected in...
Aida, Masatoshi, Chen, Yexi, Nakajima, Koichi, Yamaguchi, Yuki, Wada, Tadashi, Handa, Hiroshi
Human 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) negatively regulate transcription elongation by RNA polymerase II...
Kubo, Tomohiro, Wada, Tadashi, Yamaguchi, Yuki, Shimizu, Akira, Handa, Hiroshi
Alternative polyadenylation leads to mRNAs with variable 3′ ends. Since a 3′-untranslated region (3′-UTR) often contains cis elements that impact stability or localization of mRNA or...
Adeno-Associated Virus Site-Specific Integration Is Regulated by TRP-185▿
Yamamoto, Noriaki, Suzuki, Masato, Kawano, Masa-aki, Inoue, Takamasa, Takahashi, Ryou-u, Tsukamoto, Hiroko, ...
Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on...
Zhu, Wenyan, Wada, Tadashi, Okabe, Sachiko, Taneda, Takuya, Yamaguchi, Yuki, Handa, Hiroshi
The transcription elongation factor 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) regulates RNA polymerase II (RNAPII) processivity by promoting, in concert...
Emotional memories are not all created equal: Evidence for selective memory enhancement
Anderson, Adam K., Yamaguchi, Yuki, Grabski, Wojtek, Lacka, Dominika
Human brain imaging studies have shown that greater amygdala activation to emotional relative to neutral events leads to enhanced episodic memory. Other studies have shown that fearful faces also...
Differential Regulation of NF-κB by Elongation Factors Is Determined by Core Promoter Type▿
Amir-Zilberstein, Liat, Ainbinder, Elena, Toube, Leanne, Yamaguchi, Yuki, Handa, Hiroshi, Dikstein, Rivka
NF-κB transcription factors activate genes important for immune response, inflammation, and cell survival. P-TEFb and DSIF, which are positive and negative transcription elongation factors,...
Ando, Kozue, Hirao, Satoshi, Kabe, Yasuaki, Ogura, Yuji, Sato, Iwao, Yamaguchi, Yuki, ...
APE1/Ref-1 is thought to be a multifunctional protein involved in reduction–oxidation (redox) regulation and base excision DNA repair, and is required for early embryonic development in mice....
Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria
Azuma, Motoki, Kabe, Yasuaki, Kuramori, Chikanori, Kondo, Masao, Yamaguchi, Yuki, Handa, Hiroshi
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor...
Repression of RNA Polymerase II Elongation In Vivo Is Critically Dependent on the C-Terminus of Spt5
Chen, Hui, Contreras, Xavier, Yamaguchi, Yuki, Handa, Hiroshi, Peterlin, B. Matija, Guo, Su
The stalling of RNA polymerase II (RNAPII) at the promoters of many genes, including developmental regulators, stress-responsive genes, and HIVLTR, suggests transcription elongation as a critical...