Yukihiko Saeki

Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis (2009)

Sawada, Tetsuji, Inokuma, Shigeko, Sato, Takeo, Otsuka, Takeshi, Saeki, Yukihiko, Takeuchi, Tsutomu, ...

Objectives. The possible link between LEF and interstitial lung disease (ILD) has evoked increasing concern. The aim of the present study was to elucidate the prevalence and risk factors for newly...

Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis (2009)

Sato, Takeo, Inokuma, Shigeko, Sagawa, Akira, Matsuda, Takemasa, Takemura, Tamiko, Otsuka, Takeshi, ...

Objective. To elucidate the factors associated with poor prognosis of LEF-induced lung injury in patients with RA. Methods. The background and clinical and laboratory features of LEF-induced lung...

Isolation and Expression Profiling of Genes Upregulated in the Peripheral Blood Cells of Systemic Lupus Erythematosus Patients (2006)

Ishii, Taeko, Onda, Hiroaki, Tanigawa, Akie, Ohshima, Shiro, Fujiwara, Hiroshi, Mima, Toru, ...

We have identified the genes whose expressions are augmented in the blood cells of the patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique along with...

Isolation and Expression Profiling of Genes Upregulated in the Peripheral Blood Cells of Systemic Lupus Erythematosus Patients (2005)

Ishii, Taeko, Onda, Hiroaki, Tanigawa, Akie, Ohshima, Shiro, Fujiwara, Hiroshi, Mima, Toru, ...

We have identified the genes whose expressions are augmented in the blood cells of the patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique along with...

Interleukin 6 plays a key role in the development of antigen-induced arthritis

Ohshima, Shiro, Saeki, Yukihiko, Mima, Toru, Sasai, Mitsuko, Nishioka, Katsuhiro, Nomura, Shintaro, ...

To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis, IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a strain...

Interleukin 6 plays a key role in the development of antigen-induced arthritis

Ohshima, Shiro, Saeki, Yukihiko, Mima, Toru, Sasai, Mitsuko, Nishioka, Katsuhiro, Nomura, Shintaro, ...

To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis, IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a strain...

A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis

Atsumi, Toru, Ishihara, Katsuhiko, Kamimura, Daisuke, Ikushima, Hideto, Ohtani, Takuya, Hirota, Seiichi, ...

We generated a mouse line in which the src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-2 binding site of gp130, tyrosine 759, was mutated to phenylalanine (gp130F759/F759). The...