Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model (2008)
Ohtomo, Shuichi, Nangaku, Masaomi, Izuhara, Yuko, Takizawa, Shunya, Miyata, Toshio
Background. Chronic renal hypoxia is suspected to play a pathogenic role in the genesis of diabetic nephropathy (DN). Cobalt enhances the activity of the hypoxia-inducible factor (HIF), a key factor...
Izuhara, Yuko, Nangaku, Masaomi, Takizawa, Shunya, Takahashi, Satoru, Shao, Jing, Oishi, Hisashi, ...
Background. The reno- and cardiovascular-protective effects of angiotensin II receptor blockers (ARBs), have been ascribed, at least in part, to their ability to inhibit the formation of advanced...
Inagi, Reiko, Izuhara, Yuko, Tominaga, Naoto, Nangaku, Masaomi, Kurokawa, Kiyoshi, Miyata, Toshio
Background. We previously identified a novel serine protease inhibitor (serpin), megsin, which is predominantly expressed in the kidney. Megsin expression is up-regulated in human and experimental...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
Miyata, Toshio, Inagi, Reiko, Nangaku, Masaomi, Imasawa, Toshiyuki, Sato, Masahiro, Izuhara, Yuko, ...
Mesangial cells maintain normal glomerular function by mediating ECM remodeling and immune complex disposal. We have recently identified megsin, a novel member of the serine protease inhibitor...
Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
Miyata, Toshio, Inagi, Reiko, Nangaku, Masaomi, Imasawa, Toshiyuki, Sato, Masahiro, Izuhara, Yuko, ...
Mesangial cells maintain normal glomerular function by mediating ECM remodeling and immune complex disposal. We have recently identified megsin, a novel member of the serine protease inhibitor...