Scientific Commons: Z. Debyser

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

Pauwels, R, Andries, K, Debyser, Z, Van Daele, P, Schols, D, Stoffels, P, ...

In vitro evaluation of a large chemical library of pharmacologically acceptable prototype compounds in a high-capacity, cellular-based screening system has led to the discovery of another family of...

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

De Clercq, E, Yamamoto, N, Pauwels, R, Baba, M, Schols, D, Nakashima, H, ...

A series of bicyclams have been shown to be potent and selective inhibitors of human immunodeficiency virus (HIV). The compounds are inhibitory to the replication of various HIV-1 and HIV-2 strains...

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

Debyser, Z, Pauwels, R, Andries, K, Desmyter, J, Kukla, M, Janssen, P A, ...

Screening of pharmacologically acceptable prototype compounds has recently led to the discovery of a series of ultraselective inhibitors of human immunodeficiency virus (HIV)-1 replication, the...

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

Cherepanov, P, Surratt, D, Toelen, J, Pluymers, W, Griffith, J, De Clercq, E, ...

Integration of the human immunodeficiency virus type 1 (HIV-1) cDNA into the genome of a human cell is an essential step in the viral replication cycle. Understanding of the integration process has...

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.

Witvrouw, M, Balzarini, J, Pannecouque, C, Jhaumeer-Laulloo, S, Esté, J A, Schols, D, ...

From a series of macrocyclic diamides possessing the disulfide linkage, only SRR-SB3, a compound that complexes with zinc, was found to inhibit human immunodeficiency virus type 1 (HIV-1; strain...

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.

Pauwels, R, Andries, K, Debyser, Z, Kukla, M J, Schols, D, Breslin, H J, ...

Tetrahydro-imidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) derivatives were shown to specifically block human immunodeficiency virus type 1 (HIV-1) replication through a unique...

Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.

Thormar, H, Balzarini, J, Holy, A, Jindrich, J, Rosenberg, I, Debyser, Z, ...

A series of acyclic nucleoside phosphonate (ANP) and 2',3'-dideoxynucleoside (ddN) derivatives were evaluated for their inhibitory effects on visna virus replication and maedi/visna virus-induced...

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

De Clercq, E, Yamamoto, N, Pauwels, R, Balzarini, J, Witvrouw, M, De Vreese, K, ...

Bicyclams, in which the cyclam (1,4,8,11-tetraazacyclotetradecane) moieties are tethered via an aliphatic bridge (i.e., propylene, as in JM2763) are potent and selective inhibitors of human...