Songyang, Z, Marin, O, Donella-Deana, A, Brunati, A M, Guerra, B, ...
An eicosapeptide encompassing the C-terminal tail of c-Src (Tyr527) which is conserved in most Src-related protein kinases, is phosphorylated by C-terminal Src kinase (CSK) and by the two Src-related...
Regulation of c-Src tyrosine kinase activity by the Src SH2 domainv (1993)
Liu, X, Brodeur, SR, Gish, G, Songyang, Z, Cantley, LC, Laudano, AP, ...
The protein-tyrosine kinase activity of pp60c-src (c-Src) is inhibited by phosphorylation of tyr527, within the c-Src c-terminal tail. Genetic and biochemical data have suggested that this negative...
Regulation of c-Src tyrosine kinase activity by the Src SH2 domainv (1993)
Liu, X, Brodeur, SR, Gish, G, Songyang, Z, Cantley, LC, Laudano, AP, ...
The protein-tyrosine kinase activity of pp60c-src (c-Src) is inhibited by phosphorylation of tyr527, within the c-Src c-terminal tail. Genetic and biochemical data have suggested that this negative...
O'Bryan, J P, Songyang, Z, Cantley, L, Der, C J, Pawson, T
The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding...
Songyang, Z, Lu, K P, Kwon, Y T, Tsai, L H, Filhol, O, Cochet, C, ...
We have developed a method to study the primary sequence specificities of protein kinases by using an oriented degenerate peptide library. We report here the substrate specificities of eight protein...
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Songyang, Z, Shoelson, S E, McGlade, J, Olivier, P, Pawson, T, Bustelo, X R, ...
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a technique using a...
Birge, R B, Fajardo, J E, Reichman, C, Shoelson, S E, Songyang, Z, Cantley, L C, ...
The genome of avian sarcoma virus CT10 encodes a fusion protein in which viral Gag sequences are fused to cellular Crk sequences containing primarily Src homology 2 (SH2) and Src homology 3 (SH3)...
Boll, W, Ohno, H, Songyang, Z, Rapoport, I, Cantley, L C, Bonifacino, J S, ...
We recently determined that fusion proteins containing tyrosine-based endocytic signals bind to the mu 2 subunit of AP-2, the complex that drives clathrin coat formation and mediates endocytosis from...
Holland, S J, Gale, N W, Gish, G D, Roth, R A, Songyang, Z, Cantley, L C, ...
Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms underlying such functions, we have...
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
Yoakim, M, Hou, W, Songyang, Z, Liu, Y, Cantley, L, Schaffhausen, B
Phosphatidylinositol 3-kinase is an important element in both normal and oncogenic signal transduction. Polyomavirus middle T antigen transforms cells in a manner depending on association of its...
Panchamoorthy, G, Fukazawa, T, Stolz, L, Payne, G, Reedquist, K, Shoelson, S, ...
The Src family protein tyrosine kinases participate in signalling through cell surface receptors that lack intrinsic tyrosine kinase domains. All nine members of this family possess adjacent Src...
O'Bryan, J P, Songyang, Z, Cantley, L, Der, C J, Pawson, T
The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding...
Songyang, Z, Lu, K P, Kwon, Y T, Tsai, L H, Filhol, O, Cochet, C, ...
We have developed a method to study the primary sequence specificities of protein kinases by using an oriented degenerate peptide library. We report here the substrate specificities of eight protein...
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Songyang, Z, Shoelson, S E, McGlade, J, Olivier, P, Pawson, T, Bustelo, X R, ...
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a technique using a...
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
Yoakim, M, Hou, W, Songyang, Z, Liu, Y, Cantley, L, Schaffhausen, B
Phosphatidylinositol 3-kinase is an important element in both normal and oncogenic signal transduction. Polyomavirus middle T antigen transforms cells in a manner depending on association of its...
Panchamoorthy, G, Fukazawa, T, Stolz, L, Payne, G, Reedquist, K, Shoelson, S, ...
The Src family protein tyrosine kinases participate in signalling through cell surface receptors that lack intrinsic tyrosine kinase domains. All nine members of this family possess adjacent Src...
Birge, R B, Fajardo, J E, Reichman, C, Shoelson, S E, Songyang, Z, Cantley, L C, ...
The genome of avian sarcoma virus CT10 encodes a fusion protein in which viral Gag sequences are fused to cellular Crk sequences containing primarily Src homology 2 (SH2) and Src homology 3 (SH3)...
Boll, W, Ohno, H, Songyang, Z, Rapoport, I, Cantley, L C, Bonifacino, J S, ...
We recently determined that fusion proteins containing tyrosine-based endocytic signals bind to the mu 2 subunit of AP-2, the complex that drives clathrin coat formation and mediates endocytosis from...
Holland, S J, Gale, N W, Gish, G D, Roth, R A, Songyang, Z, Cantley, L C, ...
Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms underlying such functions, we have...