Zaal Kokaia

proliferation (2009)

Tania Aguado, Krisztina Monory, Javier Palazuelos, Nephi Stella, Benjamin Cravatt, Beat Lutz, ...

The endocannabinoid system drives neural progenitor

Regulation of Stroke-Induced Neurogenesis in Adult Brain--Recent Scientific Progress (2006)

Kokaia, Zaal, Thored, Pär, Arvidsson, Andreas, Lindvall, Olle

Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe...

The neuronal ceroid lipofuscinosis Cln8gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy (2005)

Lonka, Liina, Aalto, Antti, Kopra, Outi, Kuronen, Mervi, Kokaia, Zaal, Saarma, Mart, ...

Abstract Background The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues,...

Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats. (2002)

Andsberg, Gunnar, Kokaia, Zaal, Klein, Ronald L, Muzyczka, Nicholas, Lindvall, Olle, Mandel, Ronald J

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were continuously delivered to the striatum at biologically active levels via recombinant adeno-associated viral (rAAV) gene...

Neuronal replacement from endogenous precursors in the adult brain after stroke. (2002)

Arvidsson, Andreas, Collin, Tove, Kirik, Deniz, Kokaia, Zaal, Lindvall, Olle

In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease....

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2

Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...

Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

Bengzon, Johan, Kokaia, Zaal, Elmér, Eskil, Nanobashvili, Avtandil, Kokaia, Merab, Lindvall, Olle

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ...

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...

The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...

Inflammation is detrimental for neurogenesis in adult brain

Ekdahl, Christine T., Claasen, Jan-Hendrik, Bonde, Sara, Kokaia, Zaal, Lindvall, Olle

New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where...

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2

Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...

Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

Bengzon, Johan, Kokaia, Zaal, Elmér, Eskil, Nanobashvili, Avtandil, Kokaia, Merab, Lindvall, Olle

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ...

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...

The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...

Inflammation is detrimental for neurogenesis in adult brain

Ekdahl, Christine T., Claasen, Jan-Hendrik, Bonde, Sara, Kokaia, Zaal, Lindvall, Olle

New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where...

BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion

Rivera, Claudio, Li, Hong, Thomas-Crusells, Judith, Lahtinen, Hannele, Viitanen, Tero, Nanobashvili, Avtandil, ...

Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl− regulation, which can lead to a suppression of fast postsynaptic...