Zabrina L. Brumme

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study (2009)

Avila-Rios, Santiago, Ormsby, Christopher E, Carlson, Jonathan M, Valenzuela-Ponce, Humberto, Blanco-Heredia, Juan, Garrido-Rodriguez, Daniela, ...

Abstract Background Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level. However,...

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells (2008)

Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, ...

BackgroundVirus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under...

CD4-Dependent Characteristics of Coreceptor Use and HIV Type 1 V3 Sequence in a Large Population of Therapy-Naive Individuals (2008)

Low, Andrew J., Marchant, David, Brumme, Chanson J., Brumme, Zabrina L., Dong, Winnie, Sing, Tobias, ...

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 (2007)

Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...

Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 (2007)

Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...

Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir

Côté, Hélène C. F., Brumme, Zabrina L., Harrigan, P. Richard

We examined the prevalence of cleavage site mutations, both within and outside the gag region, in 28 protease inhibitor (PI) cross-resistant patients treated with indinavir, ritonavir, and/or...

A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance

Harrigan, P. Richard, Salim, Mahboob, Stammers, David K., Wynhoven, Brian, Brumme, Zabrina L., McKenna, Paula, ...

The Y318F substitution in the 3′ region of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been linked to nonnucleoside RT inhibitor (NNRTI) resistance in vitro. A...

Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir

Côté, Hélène C. F., Brumme, Zabrina L., Harrigan, P. Richard

We examined the prevalence of cleavage site mutations, both within and outside the gag region, in 28 protease inhibitor (PI) cross-resistant patients treated with indinavir, ritonavir, and/or...

A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance

Harrigan, P. Richard, Salim, Mahboob, Stammers, David K., Wynhoven, Brian, Brumme, Zabrina L., McKenna, Paula, ...

The Y318F substitution in the 3′ region of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been linked to nonnucleoside RT inhibitor (NNRTI) resistance in vitro. A...

Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag

Carlson, Jonathan M., Brumme, Zabrina L., Rousseau, Christine M., Brumme, Chanson J., Matthews, Philippa, Kadie, Carl, ...

HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among...

Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes▿

Miura, Toshiyuki, Brockman, Mark A., Brumme, Chanson J., Brumme, Zabrina L., Carlson, Jonathan M., Pereyra, Florencia, ...

Despite reports of viral genetic defects in persons who control human immunodeficiency virus type 1 (HIV-1) in the absence of antiviral therapy, the extent to which such defects contribute to the...

Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection ▿

Brumme, Zabrina L., Brumme, Chanson J., Carlson, Jonathan, Streeck, Hendrik, John, Mina, Eichbaum, Quentin, ...

During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely...

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

Streeck, Hendrik, Brumme, Zabrina L, Anastario, Michael, Cohen, Kristin W, Jolin, Jonathan S, Meier, Angela, ...

Marcus Altfeld and colleagues suggest that the exhaustion of virus-specific CD8+ T cells during chronic HIV infection likely results from the persistence of antigen.

HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1 ▿

Miura, Toshiyuki, Brockman, Mark A., Brumme, Zabrina L., Brumme, Chanson J., Pereyra, Florencia, Trocha, Alicja, ...

Human immunodeficiency virus type 1 (HIV-1)-infected persons who maintain plasma viral loads of

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

Brumme, Zabrina L., John, Mina, Carlson, Jonathan M., Brumme, Chanson J., Chan, Dennison, Brockman, Mark A., ...

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study

Avila-Rios, Santiago, Ormsby, Christopher E, Carlson, Jonathan M, Valenzuela-Ponce, Humberto, Blanco-Heredia, Juan, Garrido-Rodriguez, Daniela, ...

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition▿

Miura, Toshiyuki, Brockman, Mark A., Schneidewind, Arne, Lobritz, Michael, Pereyra, Florencia, Rathod, Almas, ...

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit of commercial assay detection (

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers▿

Miura, Toshiyuki, Brumme, Chanson J., Brockman, Mark A., Brumme, Zabrina L., Pereyra, Florencia, Block, Brian L., ...

Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are...

Transmission and Long-Term Stability of Compensated CD8 Escape Mutations▿

Schneidewind, Arne, Brumme, Zabrina L., Brumme, Chanson J., Power, Karen A., Reyor, Laura L., O'Sullivan, Kristin, ...

Human immunodeficiency virus effectively evades CD8+ T-cell responses through the development of CD8 escape mutations. Recent reports documenting reversion of transmitted mutations and the impact of...