Zach N. Adelman

RNA Silencing of Dengue Virus Type 2 Replication in Transformed C6/36 Mosquito Cells Transcribing an Inverted-Repeat RNA Derived from the Virus Genome

Adelman, Zach N., Sanchez-Vargas, Irma, Travanty, Emily A., Carlson, Jon O., Beaty, Barry J., Blair, Carol D., ...

Double-stranded RNA (dsRNA) initiates cellular posttranscriptional responses that are collectively called RNA silencing in a number of different organisms, including plants, nematodes, and fruit...

Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti

Franz, Alexander W. E., Sanchez-Vargas, Irma, Adelman, Zach N., Blair, Carol D., Beaty, Barry J., James, Anthony A., ...

Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in...

RNA Silencing of Dengue Virus Type 2 Replication in Transformed C6/36 Mosquito Cells Transcribing an Inverted-Repeat RNA Derived from the Virus Genome

Adelman, Zach N., Sanchez-Vargas, Irma, Travanty, Emily A., Carlson, Jon O., Beaty, Barry J., Blair, Carol D., ...

Double-stranded RNA (dsRNA) initiates cellular posttranscriptional responses that are collectively called RNA silencing in a number of different organisms, including plants, nematodes, and fruit...

Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti

Franz, Alexander W. E., Sanchez-Vargas, Irma, Adelman, Zach N., Blair, Carol D., Beaty, Barry J., James, Anthony A., ...

Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in...

nanos gene control DNA mediates developmentally regulated transposition in the yellow fever mosquito Aedes aegypti

Adelman, Zach N., Jasinskiene, Nijole, Onal, Sedef, Juhn, Jennifer, Ashikyan, Aurora, Salampessy, Michael, ...

Transposable elements (TEs) are proposed as a basis for developing drive systems to spread pathogen resistance genes through vector mosquito populations. The use of transcriptional and translational...

Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes

Myles, Kevin M., Wiley, Michael R., Morazzani, Elaine M., Adelman, Zach N.

Mosquito-borne viruses cause significant levels of morbidity and mortality in humans and domesticated animals. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle...

Accurate Strand-Specific Quantification of Viral RNA

Plaskon, Nicole E., Adelman, Zach N., Myles, Kevin M.

The presence of full-length complements of viral genomic RNA is a hallmark of RNA virus replication within an infected cell. As such, methods for detecting and measuring specific strands of viral RNA...