A burst of segmental duplications in the genome of the African great ape ancestor (2009)
Marqués-Bonet, Tomàs, Kidd, Jeffrey M., Ventura, Mario, Graves, Tina A., Cheng, Ze, Hillier, LaDeana W., ...
5 pages, 4 figures.-- Supplementary information (3 files) available at: http://www.nature.com/nature/journal/v457/n7231/suppinfo/nature07744.html
Nicholas, Thomas J., Cheng, Ze, Ventura, Mario, Mealey, Katrina, Eichler, Evan E., Akey, Joshua M.
Structural variation is an important and abundant source of genetic and phenotypic variation. Here we describe the first systematic and genome-wide analysis of segmental duplications and associated...
Marques-Bonet, Tomàs, Cheng, Ze, She, Xinwei, Eichler, Evan E, Navarro, Arcadi
Abstract Background It has been suggested that chromosomal rearrangements harbor the molecular footprint of the biological phenomena which they induce, in the form, for instance, of changes in the...
Genome analysis of the platypus reveals unique signatures of evolution (2008)
Warren, Wesley C., Hillier, LaDeana W., Marshall Graves, Jennifer A., Birney, Ewan, Ponting, Chris P., Grützner, Frank, ...
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a...
Haplotype sorting using human fosmid clone end-sequence pairs (2008)
Kidd, Jeffrey M., Cheng, Ze, Graves, Tina, Fulton, Bob, Wilson, Richard K., Eichler, Evan E.
An important goal of human genetics and genomics is to understand the complete spectrum of genetic variation across a specific human haplotype. By combining information from a dense SNP map with...
Kirsch, Stefan, Münch, Claudia, Jiang, Zhaoshi, Cheng, Ze, Chen, Lin, Batz, Christiane, ...
Human chromosomal regions enriched in segmental duplications are subject to extensive genomic reorganization. Such regions are particularly informative for illuminating the evolutionary history of a...
Optimal design of oligonucleotide microarrays for measurement of DNA copy-number (2007)
Sharp, Andrew J., Itsara, Andy, Cheng, Ze, Alkan, Can, Schwartz, Stuart, Eichler, Evan E.
Copy-number variants (CNVs) occur frequently within the human genome, and may be associated with many human phenotypes. If disease association studies of CNVs are to be performed routinely, it is...
Recurrent duplication-driven transposition of DNA during hominoid evolution. (2006)
Johnson, Matthew E., Cheng, Ze, Morrison, V. Anne, Scherer, Steven, Ventura, Mario, Gibbs, Richard A., ...
The underlying mechanism by which the interspersed pattern of human segmental duplications has evolved is unknown. Based on a comparative analysis of primate genomes, we show that a particular...
Molecular refinement of gibbon genome rearrangement (2006)
Roberto, Roberta, Capozzi, Oronzo, Wilson, Richard K., Mardis, Elaine R., Lomiento, Mariana, Tuzun, Eray, ...
The gibbon karyotype is known to be extensively rearranged when compared to the human and to the ancestral primate karyotype. By combining a bioinformatics (paired-end sequence analysis) approach and...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
A neural-based CAD tool for RF/microwave modeling. (2005)
Thesis (M.A.Sc.) -- University of Ottawa, 2005.
A neural-based CAD tool for RF/microwave modeling [microform]. (2005)
Thesis (M.A.Sc.) -- University of Ottawa, 2005.
Segmental duplications and copy-number variation in the human genome. (2005)
Sharp, Andrew J., Locke, Devin P., McGrath, Sean D., Cheng, Ze, Bailey, Jeffrey A., Vallente, Rhea U., ...
The human genome contains numerous blocks of highly homologous duplicated sequence. This higher-order architecture provides a substrate for recombination and recurrent chromosomal rearrangement...
Thesis (M.S.)--University of Alaska Fairbanks, 1994.
Segmental Duplications and Copy-Number Variation in the Human Genome
Sharp, Andrew J., Locke, Devin P., McGrath, Sean D., Cheng, Ze, Bailey, Jeffrey A., Vallente, Rhea U., ...
The human genome contains numerous blocks of highly homologous duplicated sequence. This higher-order architecture provides a substrate for recombination and recurrent chromosomal rearrangement...
Locke, Devin P., Sharp, Andrew J., McCarroll, Steven A., McGrath, Sean D., Newman, Tera L., Cheng, Ze, ...
Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded complex regions of the genome that are rich in duplications and prone to rearrangement. In an attempt to...
Recurrent duplication-driven transposition of DNA during hominoid evolution
Johnson, Matthew E., Cheng, Ze, Morrison, V. Anne, Scherer, Steven, Ventura, Mario, Gibbs, Richard A., ...
The underlying mechanism by which the interspersed pattern of human segmental duplications has evolved is unknown. Based on a comparative analysis of primate genomes, we show that a particular...
A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome
Wong, Kendy K., DeLeeuw, Ronald J., Dosanjh, Nirpjit S., Kimm, Lindsey R., Cheng, Ze, Horsman, Douglas E., ...
Segmental copy-number variations (CNVs) in the human genome are associated with developmental disorders and susceptibility to diseases. More importantly, CNVs may represent a major genetic component...
Molecular refinement of gibbon genome rearrangements
Roberto, Roberta, Capozzi, Oronzo, Wilson, Richard K., Mardis, Elaine R., Lomiento, Mariana, Tuzun, Eray, ...
The gibbon karyotype is known to be extensively rearranged when compared to the human and to the ancestral primate karyotype. By combining a bioinformatics (paired-end sequence analysis) approach and...
Kirsch, Stefan, Münch, Claudia, Jiang, Zhaoshi, Cheng, Ze, Chen, Lin, Batz, Christiane, ...
Human chromosomal regions enriched in segmental duplications are subject to extensive genomic reorganization. Such regions are particularly informative for illuminating the evolutionary history of a...
Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse
Church, Deanna M., Goodstadt, Leo, Hillier, LaDeana W., Zody, Michael C., Goldstein, Steve, She, Xinwe, ...
A finished clone-based assembly of the mouse genome reveals extensive recent sequence duplication during recent evolution and rodent-specific expansion of certain gene families. Newly assembled...
Haplotype sorting using human fosmid clone end-sequence pairs
Kidd, Jeffrey M., Cheng, Ze, Graves, Tina, Fulton, Bob, Wilson, Richard K., Eichler, Evan E.
An important goal of human genetics and genomics is to understand the complete spectrum of genetic variation across a specific human haplotype. By combining information from a dense SNP map with...
The genomic architecture of segmental duplications and associated copy number variants in dogs
Nicholas, Thomas J., Cheng, Ze, Ventura, Mario, Mealey, Katrina, Eichler, Evan E., Akey, Joshua M.
Structural variation is an important and abundant source of genetic and phenotypic variation. Here we describe the first systematic and genome-wide analysis of segmental duplications and associated...