Population Genetics and Linkage Analysis of Loci within the FCT Region of Streptococcus pyogenes▿ †
Kratovac, Zerina, Manoharan, Anand, Luo, Feng, Lizano, Sergio, Bessen, Debra E.
The FCT regions of Streptococcus pyogenes strains encode a variety of cell wall-anchored surface proteins that bind the extracellular matrix of the human host and/or give rise to pilus-like...
Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species
Virgen, Cesar A., Kratovac, Zerina, Bieniasz, Paul D., Hatziioannou, Theodora
The host range of retroviruses is influenced by antiviral proteins such as TRIM5, a restriction factor that recognizes and inactivates incoming retroviral capsids. Remarkably, in Owl monkeys (omk), a...
Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins▿
Kratovac, Zerina, Virgen, Cesar A., Bibollet-Ruche, Frederick, Hahn, Beatrice H., Bieniasz, Paul D., Hatziioannou, Theodora
Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming...
Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin▿
Jouvenet, Nolwenn, Neil, Stuart J. D., Zhadina, Maria, Zang, Trinity, Kratovac, Zerina, Lee, Youngnam, ...
The expression of many putative antiviral genes is upregulated when cells encounter type I interferon (IFN), but the actual mechanisms by which many IFN-induced gene products inhibit virus...