Abstract Background Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance...
Disease Gene Mapping in General (2009)
R. Browning, Li Li, Sharon R. Browning, Zhao-bang Zeng
Disease gene mapping is one of the main focuses of genetic epidemiology and statistical genetics. This dissertation explores some methods and algorithms in this area, especially in pedigrees. The...
Huang, Lingkang, Heinloth, Alexandra N, Zeng, Zhao-Bang, Paules, Richard S, Bushel, Pierre R
Abstract Background Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to hepatotoxicants is a complex...
Tao Wang, Bruce Weir, Zhao-bang Zeng
A population-based latent variable approach is proposed for association mapping of quantitative trait loci (QTL), using multiple closely linked genetic markers within a small candidate region in the...
Statistical Methods for Mapping Multiple QTL (2008)
Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical...
Statistical Methods for Mapping Multiple QTL (2008)
Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical...
Changjian Jiang, Zhao-bang Zeng
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eQTL Viewer: visualizing how sequence variation affects genome-wide transcription (2007)
Zou, Wei, Aylor, David L, Zeng, Zhao-Bang
Abstract Background Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expression...
To find the correlations between genome-wide gene expression variations and sequence poly-morphisms in inbred populations, we developed a statistical method to claim expression quan-titative trait...
Abstract Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and...
Theoretical Population Biology 61, 349--363 (2002) (2002)
Doi Tpbi Available, Rongling Wu, Chang-xing Ma, Ian Painter, Zhao-bang Zeng
this paper, we present a general maximumlikelihood -based algorithm for simultaneously estimating linkage and linkage phases for a mixed set of different marker types containing fully informative...
Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
Nuzhdin, Sergey V., Pasyukova, Elena G., Dilda, Christy L., Zeng, Zhao-Bang, Mackay, Trudy F. C.
Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural...
The Selection Limit Due to the Conflict between Truncation and Stabilizing Selection with Mutation
Zeng, Zhao-Bang, Hill, William G.
Long-term selection response could slow down from a decline in genetic variance or in selection differential or both. A model of conflict between truncation and stabilizing selection in infinite...
Modeling Quantitative Trait Loci and Interpretation of Models
Zeng, Zhao-Bang, Wang, Tao, Zou, Wei
A quantitative genetic model relates the genotypic value of an individual to the alleles at the loci that contribute to the variation in a population in terms of additive, dominance, and epistatic...
Genetic Architecture of Transcript-Level Variation in Differentiating Xylem of a Eucalyptus Hybrid
Kirst, Matias, Basten, Christopher J., Myburg, Alexander A., Zeng, Zhao-Bang, Sederoff, Ronald R.
Species diversity may have evolved by differential regulation of a similar set of genes. To analyze and compare the genetic architecture of transcript regulation in different genetic backgrounds of...
Modeling epistasis of quantitative trait loci using Cockerham's model.
Kao, Chen-Hung, Zeng, Zhao-Bang
We use the orthogonal contrast scales proposed by Cockerham to construct a genetic model, called Cockerham's model, for studying epistasis between genes. The properties of Cockerham's model in...
Tao, Yun, Zeng, Zhao-Bang, Li, Jian, Hartl, Daniel L, Laurie, Cathy C
Hybrid male sterility (HMS) is a rapidly evolving mechanism of reproductive isolation in Drosophila. Here we report a genetic analysis of HMS in third-chromosome segments of Drosophila mauritiana...
Multiple-Interval Mapping for Ordinal Traits
Li, Jian, Wang, Shengchu, Zeng, Zhao-Bang
Many statistical methods have been developed to map multiple quantitative trait loci (QTL) in experimental cross populations. Among these methods, multiple-interval mapping (MIM) can map QTL with...
Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
Nuzhdin, Sergey V., Pasyukova, Elena G., Dilda, Christy L., Zeng, Zhao-Bang, Mackay, Trudy F. C.
Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural...
The Selection Limit Due to the Conflict between Truncation and Stabilizing Selection with Mutation
Zeng, Zhao-Bang, Hill, William G.
Long-term selection response could slow down from a decline in genetic variance or in selection differential or both. A model of conflict between truncation and stabilizing selection in infinite...
Modeling Quantitative Trait Loci and Interpretation of Models
Zeng, Zhao-Bang, Wang, Tao, Zou, Wei
A quantitative genetic model relates the genotypic value of an individual to the alleles at the loci that contribute to the variation in a population in terms of additive, dominance, and epistatic...
Genetic Architecture of Transcript-Level Variation in Differentiating Xylem of a Eucalyptus Hybrid
Kirst, Matias, Basten, Christopher J., Myburg, Alexander A., Zeng, Zhao-Bang, Sederoff, Ronald R.
Species diversity may have evolved by differential regulation of a similar set of genes. To analyze and compare the genetic architecture of transcript regulation in different genetic backgrounds of...
Modeling epistasis of quantitative trait loci using Cockerham's model.
Kao, Chen-Hung, Zeng, Zhao-Bang
We use the orthogonal contrast scales proposed by Cockerham to construct a genetic model, called Cockerham's model, for studying epistasis between genes. The properties of Cockerham's model in...
Tao, Yun, Zeng, Zhao-Bang, Li, Jian, Hartl, Daniel L, Laurie, Cathy C
Hybrid male sterility (HMS) is a rapidly evolving mechanism of reproductive isolation in Drosophila. Here we report a genetic analysis of HMS in third-chromosome segments of Drosophila mauritiana...
Multiple-Interval Mapping for Ordinal Traits
Li, Jian, Wang, Shengchu, Zeng, Zhao-Bang
Many statistical methods have been developed to map multiple quantitative trait loci (QTL) in experimental cross populations. Among these methods, multiple-interval mapping (MIM) can map QTL with...
A Semiparametric Approach for Composite Functional Mapping of Dynamic Quantitative Traits
Yang, Runqing, Gao, Huijiang, Wang, Xin, Zhang, Ji, Zeng, Zhao-Bang, Wu, Rongling
Functional mapping has emerged as a powerful tool for mapping quantitative trait loci (QTL) that control developmental patterns of complex dynamic traits. Original functional mapping has been...
From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis
Aylor, David L., Zeng, Zhao-Bang
Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis,...
Statistical Methods for Mapping Multiple QTL
Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical...
Quantitative Trait Loci Mapping and The Genetic Basis of Heterosis in Maize and Rice
Garcia, Antonio Augusto Franco, Wang, Shengchu, Melchinger, Albrecht E., Zeng, Zhao-Bang
Despite its importance to agriculture, the genetic basis of heterosis is still not well understood. The main competing hypotheses include dominance, overdominance, and epistasis. NC design III is an...