Zhelong Xu

Ethanol Prevents Oxidant-Induced Mitochondrial Permeability Transition Pore Opening in Cardiac Cells (2009)

Zhou, Kunyan, Zhang, Lei, Xi, Jinkun, Tian, Wei, Xu, Zhelong

Aims: The purpose of this study was to determine if ethanol prevents the mitochondrial permeability transition pore (mPTP) opening via glycogen synthase kinase 3β (GSK-3β). Methods: Cardiac H9c2...

NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes (2007)

Jang, Youngho, Wang, Huihua, Xi, Jinkun, Mueller, Robert A., Norfleet, Edward A., Xu, Zhelong

Objective Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular free zinc (Zn2+). Methods Zn2+ levels were determined by imaging enzymatically...

Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes (2005)

Xu, Zhelong, Park, Sung-Sik, Mueller, Robert A., Bagnell, Robert C., Patterson, Cam, Boysen, Philip G.

Objective: To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. Methods and results: Adenosine significantly enhanced the...

Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3β

Chanoit, Guillaume, Lee, SungRyul, Xi, Jinkun, Zhu, Min, McIntosh, Rachel A., Mueller, Robert A., ...

The purpose of this study was to determine whether exogenous zinc prevents cardiac reperfusion injury by targeting the mitochondrial permeability transition pore (mPTP) via glycogen synthase...