Zhengqing You

Substituent effects on the genotoxicity of 4-nitrostilbene derivatives (1994)

Hooberman, Barry H., Brezzell, M. D., Das, S. K., You, Zhengqing, Sinsheimer, Joseph E.

4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo...

Substituent effects on the in vitro and in vivo genotoxicity of 4-aminobiphenyl and 4-aminostilbene derivatives (1994)

You, Zhengqing, Brezzell, M. D., Das, S. K., Hooberman, Barry H., Sinsheimer, Joseph E.

4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with...

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives (1993)

You, Zhengqing, Brezzell, M. D., Das, S. K., Espadas-Torre, M. C., Hooberman, Barry H., Sinsheimer, Joseph E.

Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and...

Axial selectivity of 1,2-nucleophilic additions to 2-(Alkylidene)cyclohexanones: Is it higher than that of 2-cyclohexenones? (1993)

You, Zhengqing, Koreeda, Masato

2-(Alkylidene)cyclohexanones embedded in steroid systems underwent 1,2-addition of both small and sterically demanding nucleophiles to yield exclusively the axial adducts, supporting the suggestion...

The genotoxicity of enantiomeric aliphatic epoxides (1993)

Sinsheimer, Joseph E., Chen, R., Das, S. K., Hooberman, Barry H., Osorio, S., You, Zhengqing

The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide,...

Enantioselective detoxication of optical isomers of glycidyl ethers (1993)

Chen, Ruth R., Nguyen, Phuong, You, Zhengqing, Sinsheimer, Joseph E.

The detoxication of the enantiomers of glycidyl 4-nitrophenyl ether (GNPE), (−)-(R)- and (+)-(S)-GNPE, and glycidyl 1-naphthyl ether (GNE), (−)-(R)- and (+)-(S)-GNE, by rat liver glutathione...

The in vivo and in vitro genotoxicity of aromatic amines in relationship to the genotoxicity of benzidine (1992)

Sinsheimer, Joseph E., Hooberman, Barry H., Das, S. K., Brezzell, M. D., You, Zhengqing

Benzidine and 12 related aromatic amines have been studied for the effects of substituent groups and [pi] orbital conjugation on their genotoxicity as measured by their mutagenicity in vitro with...

NUCLEOPHILIC ADDITIONS TO A HINDERED 2-(ALKYLIDENE)CYCLOHEXANONE AND SYNTHESIS OF 1,3,5-TRIMETHYLATED CARBON CHAIN COMPOUNDS THROUGH CHIRALITY TRANSFER STRATEGIES. (1989)

YOU, ZHENGQING

An efficient, highly stereoselective methodology utilizing cyclohexenones for the synthesis of 1,3,5-trimethylated carbon chain compounds has been established.