A compact VEGF signature associated with distant metastases and poor outcomes (2009)
Hu, Zhiyuan, Fan, Cheng, Livasy, Chad, He, Xiaping, Oh, Daniel S, Ewend, Matthew G, ...
Abstract Background Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies....
Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Abstract Background Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To...
The molecular portraits of breast tumors are conserved across microarray platforms (2006)
Hu, Zhiyuan, Fan, Cheng, Oh, Daniel S, Marron, JS, He, Xiaping, Qaqish, Bahjat F, ...
Abstract Background Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification....
The molecular portraits of breast tumors are conserved acress microarray platforms (2006)
Hu, Zhiyuan, Fan, Cheng, Oh, Daniel S., Marron, J. S., He, Xiaping, Qaqish, Bahjat F., ...
BackgroundValidation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However,...
Perreard, Laurent, Fan, Cheng, Quackenbush, John F, Mullins, Michael, Gauthier, Nicholas P, Nelson, Edward, ...
Abstract Introduction Predicting the clinical course of breast cancer is often difficult because it is a diverse disease comprised of many biological subtypes. Gene expression profiling by microarray...
Altered Growth of Transgenic Tobacco Lacking Leaf Cytosolic Pyruvate Kinase1
Knowles, Vicki L., McHugh, Sylvia G., Hu, Zhiyuan, Dennis, David T., Miki, Brian L., Plaxton, William C.
Previously, we reported that transformation of tobacco (Nicotiana tabacum L.) with a vector containing a potato cytosolic pyruvate kinase (PKc) cDNA generated two plant lines specifically lacking...
Hypothalamic malonyl-CoA as a mediator of feeding behavior
Hu, Zhiyuan, Cha, Seung Hun, Chohnan, Shigeru, Lane, M. Daniel
Previous studies showed that i.p. administration of C75, a potent inhibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptides and down-regulation of...
Cha, Seung Hun, Hu, Zhiyuan, Chohnan, Shigeru, Lane, M. Daniel
Malonyl-CoA functions as a mediator in the hypothalamic sensing of energy balance and regulates the neural physiology that governs feeding behavior and energy expenditure. The central administration...
The molecular portraits of breast tumors are conserved across microarray platforms
Hu, Zhiyuan, Fan, Cheng, Oh, Daniel S, Marron, JS, He, Xiaping, Qaqish, Bahjat F, ...
Two FAD3 Desaturase Genes Control the Level of Linolenic Acid in Flax Seed
Vrinten, Patricia, Hu, Zhiyuan, Munchinsky, Mary-Ann, Rowland, Gordon, Qiu, Xiao
Industrial oil flax (Linum usitatissimum) and edible oil or solin flax differ markedly in seed linolenic acid levels. Despite the economic importance of low-linolenic-acid or solin flax, the...
Perreard, Laurent, Fan, Cheng, Quackenbush, John F, Mullins, Michael, Gauthier, Nicholas P, Nelson, Edward, ...
Altered Growth of Transgenic Tobacco Lacking Leaf Cytosolic Pyruvate Kinase1
Knowles, Vicki L., McHugh, Sylvia G., Hu, Zhiyuan, Dennis, David T., Miki, Brian L., Plaxton, William C.
Previously, we reported that transformation of tobacco (Nicotiana tabacum L.) with a vector containing a potato cytosolic pyruvate kinase (PKc) cDNA generated two plant lines specifically lacking...
Hypothalamic malonyl-CoA as a mediator of feeding behavior
Hu, Zhiyuan, Cha, Seung Hun, Chohnan, Shigeru, Lane, M. Daniel
Previous studies showed that i.p. administration of C75, a potent inhibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptides and down-regulation of...
Hu, Zhiyuan, Cha, Seung Hun, Van Haasteren, Goedelle, Wang, Jing, Lane, M. Daniel
The central administration of the fatty acid synthase (FAS) inhibitor, C75, rapidly suppresses the expression of orexigenic neuropeptides [neuropeptide Y (NPY) and agouti-related protein (AgRP)] and...
Two FAD3 Desaturase Genes Control the Level of Linolenic Acid in Flax Seed
Vrinten, Patricia, Hu, Zhiyuan, Munchinsky, Mary-Ann, Rowland, Gordon, Qiu, Xiao
Industrial oil flax (Linum usitatissimum) and edible oil or solin flax differ markedly in seed linolenic acid levels. Despite the economic importance of low-linolenic-acid or solin flax, the...
Cha, Seung Hun, Hu, Zhiyuan, Chohnan, Shigeru, Lane, M. Daniel
Malonyl-CoA functions as a mediator in the hypothalamic sensing of energy balance and regulates the neural physiology that governs feeding behavior and energy expenditure. The central administration...
The molecular portraits of breast tumors are conserved across microarray platforms
Hu, Zhiyuan, Fan, Cheng, Oh, Daniel S, Marron, JS, He, Xiaping, Qaqish, Bahjat F, ...
Perreard, Laurent, Fan, Cheng, Quackenbush, John F, Mullins, Michael, Gauthier, Nicholas P, Nelson, Edward, ...
Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human...
Zhang, Binghua, Zhang, Yanqiong, Wang, Jiwei, Zhang, Yangde, Chen, Jiji, Pan, Yifeng, ...
Ligands specific to cell surface receptors have been heavily investigated in cancer research. Phage display technology is a powerful tool in this field and may impact clinical issues including...
Brain fatty acid synthase activates PPARα to maintain energy homeostasis
Chakravarthy, Manu V., Zhu, Yimin, López, Miguel, Yin, Li, Wozniak, David F., Coleman, Trey, ...
Central nervous system control of energy balance affects susceptibility to obesity and diabetes, but how fatty acids, malonyl-CoA, and other metabolites act at this site to alter metabolism is poorly...
Molecular Characterization of Human Breast Tumor Vascular Cells
Bhati, Rajendra, Patterson, Cam, Livasy, Chad A., Fan, Cheng, Ketelsen, David, Hu, Zhiyuan, ...
A detailed understanding of the assortment of genes that are expressed in breast tumor vessels is needed to facilitate the development of novel, molecularly targeted anti-angiogenic agents for breast...
A compact VEGF signature associated with distant metastases and poor outcomes
Hu, Zhiyuan, Fan, Cheng, Livasy, Chad, He, Xiaping, Oh, Daniel S, Ewend, Matthew G, ...
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Wang, Kai, Zhang, Shile, Marzolf, Bruz, Troisch, Pamela, Brightman, Amy, Hu, Zhiyuan, ...
Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant threat to patient health and has an enormous economic impact on health care expenditures. Numerous efforts...