A protein domain-based interactome network for C. elegans early embryogenesis (2008)
Boxem, Mike, Maliga, Zoltan, Klitgord, Niels, Li, Na, Lemmens, Irma, Mana, Miyeko, ...
Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored...
Nieland, Thomas J. F., Shaw, Jared T., Jaipuri, Firoz A., Maliga, Zoltan, Duffner, Jay L., Koehler, Angela N., ...
Treatment of atherosclerotic disease often focuses on reducing plasma LDL-cholesterol or increasing plasma HDL-cholesterol. We examined in vitro the effects on HDL receptor [scavenger receptor class...
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol (2006)
Maliga, Zoltan, Mitchison, Timothy J
Abstract Background A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational...
Dissecting kinesin motor function with small-molecule inhibitors / (2004)
Thesis (Ph.D., Dept. of Biophysics)--Harvard University, 2004.
Mechanistic Analysis of the Mitotic Kinesin Eg5*
Cochran, Jared C., Sontag, Christopher A., Maliga, Zoltan, Kapoor, Tarun M., Correia, John J., Gilbert, Susan P.
Eg5 is a slow, plus-end-directed microtubule-based motor of the BimC kinesin family that is essential for bipolar spindle formation during eukaryotic cell division. We have analyzed two human Eg5/KSP...