Smith, Theresa J., Guo, Zuyu, Guengerich, F.Peter, Yang, Chung S.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco-specific nitrosamine in animals and has been suggested to play a role in human tobacco-related cancers. Our previous study...
Shimada, Tsutomu, Gillam, Elizabeth M.J., Sandhu, Punam, Guo, Zuyu, Tukey, Robert H., Guengerich, F.Peter
Bacterial assays were used to examine the activation of 14 known procarcinogens by cytochrome P450 (P450) enzymestâ . Human P450s 1A1, 1A2 and 3A4 were expressed in Escherichia coil with slight...
Guo, Zuyu, Smith, Theresa J., Wang, Erjia, Eklind, Karin I., Chung, Fung-Lung, Yang, Chung S.
Many arylalkyl isothiocyanates are potent inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in rats and mice. In the mouse, 4-phenylbutyl isothiocyanate...
"Joint Graduate Program in Biochemistry."
Guo, Zuyu, Smith, Theresa J., Wang, Erjia, Sadrieh, Nakissa, Ma, Qiang, Thomas, Paul E, ...
Phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables, has been shown to inhibit chemical carcinogenesis, possibly due to its ability to block the activation or to enhance the...
Smith, Theresa J., Guo, Zuyu, Jun-Hong, Yan, Ning, Shu M., Thomas, Paul E., Yang, Chung S.
The rat lung and nasal cavity are two target organs for carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In order to characterize further the enzymes involved in the...
Guo, Zuyu, Smith, Theresa J., Ishizaki, Hiroyuki, Yang, Chung S.
Several previous studies have suggested that cytochrome P450IIB1 is involved in the bioactivation of the tobaccospecific carcinogen, 4-(methylnitrosamino)-1-(3-pyridy1)-1-butanone (NNK), in rat as...