Zuzana Valnickova

Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI) (2009)

Valnickova, Zuzana, Thaysen-Andersen, Morten, Højrup, Peter, Christensen, Trine, Sanggaard, Kristian W, Kristensen, Torsten, ...

Abstract Background TAFI is a plasma protein assumed to be an important link between coagulation and fibrinolysis. The three-dimensional crystal structures of authentic mature bovine TAFI (TAFIa) in...

BMC Biochemistry BioMed Central (2009)

Zuzana Valnickova, Morten Thaysen-andersen, Peter Højrup, Trine Christensen, Kristian W Sanggaard, Torsten Kristensen, ...

Research article Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI)

The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulate enzymatic activity (2007)

Petersen, Steen V, Valnickova, Zuzana, Oury, Tim D, Crapo, James D, Chr Nielsen, Niels, Enghild, Jan J

Abstract Background Human extracellular superoxide dismutase (EC-SOD) is a tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space. We have previously...

The dual nature of human extracellular superoxide dismutase: One sequence and two structures

Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...

Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...

The high concentration of Arg213→Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities

Petersen, Steen V., Olsen, Dorte Aa., Kenney, John M., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., ...

The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen. A mutation (Arg213→Gly; R213G) within this...

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.

Petersen, Steen V, Valnickova, Zuzana, Enghild, Jan J

Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that...

The dual nature of human extracellular superoxide dismutase: One sequence and two structures

Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...

Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...

The high concentration of Arg213→Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities

Petersen, Steen V., Olsen, Dorte Aa., Kenney, John M., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., ...

The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen. A mutation (Arg213→Gly; R213G) within this...

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.

Petersen, Steen V, Valnickova, Zuzana, Enghild, Jan J

Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that...

Potential Clinical Importance of the Activation Peptide of Prostate-specific Antigen

Voeghtly, Laura M., Thøgersen, Ida B., Valnickova, Zuzana, Sanggaard, Kristian W., Chu, Charleen T., Oury, Tim D., ...

Prostate cancer is the second leading cause of cancer death in men. Prostate specific antigen (PSA) is currently the best marker available for screening and monitoring disease recurrence, but its use...

The Crystal Structure of Thrombin-activable Fibrinolysis Inhibitor (TAFI) Provides the Structural Basis for Its Intrinsic Activity and the Short Half-life of TAFIa*♦

Anand, Kanchan, Pallares, Irantzu, Valnickova, Zuzana, Christensen, Trine, Vendrell, Josep, Wendt, K. Ulrich, ...

Mature thrombin-activable fibrinolysis inhibitor (TAFIa) is a highly unstable metallocarboxypeptidase that stabilizes blood clots by clipping C-terminal lysine residues from partially degraded...