Scientific Commons: Zvi Livneh

Repair of gaps opposite lesions by homologous recombination in mammalian cells (2009)

Adar, Sheera, Izhar, Lior, Hendel, Ayal, Geacintov, Nicholas, Livneh, Zvi

Damages in the DNA template inhibit the progression of replication, which may cause single-stranded gaps. Such situations can be tolerated by translesion DNA synthesis (TLS), or by homology-dependent...

Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells (2009)

Covo, Shay, De Villartay, Jean-Pierre, Jeggo, Penny A., Livneh, Zvi

Double strand breaks (DSB) are severe DNA lesions, and if not properly repaired, may lead to cell death or cancer. While there is considerable data on the repair of simple DSB (sDSB) by...

DNA Repair Activity for Oxidative Damage and Risk of Lung Cancer (2003)

Paz-Elizur, Tamar, Krupsky, Meir, Blumenstein, Sara, Elinger, Dalia, Schechtman, Edna, Livneh, Zvi

Background: Although smoking is a major cause of lung cancer, only a proportion of smokers develop lung cancer, suggesting a genetic predisposition in some individuals. Because tobacco smoking is...

Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis

Maor-Shoshani, Ayelet, Reuven, Nina Bacher, Tomer, Guy, Livneh, Zvi

When challenged by DNA-damaging agents, Escherichia coli cells respond by inducing the SOS stress response, which leads to an increase in mutation frequency by two mechanisms: translesion...

Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA′, RecA, and SSB

Goldsmith, Moshe, Sarov-Blat, Lea, Livneh, Zvi

Replication through damaged sites in DNA requires in Escherichia coli the SOS stress-inducible DNA polymerase V (UmuC), which is specialized for lesion bypass. Homologs of the umuC gene were found on...

The β subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme

Tomer, Guy, Reuven, Nina Bacher, Livneh, Zvi

The replication of damaged nucleotides that have escaped DNA repair leads to the formation of mutations caused by misincorporation opposite the lesion. In Escherichia coli, this process is under...

Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase

Avkin, Sharon, Adar, Sheera, Blander, Gil, Livneh, Zvi

Mutations in oncogenes and tumor suppressor genes are critical in the development of cancer. A major pathway for the formation of mutations is the replication of unrepaired DNA lesions. To better...

DNA molecule provides a computing machine with both data and fuel

Benenson, Yaakov, Adar, Rivka, Paz-Elizur, Tamar, Livneh, Zvi, Shapiro, Ehud

The unique properties of DNA make it a fundamental building block in the fields of supramolecular chemistry, nanotechnology, nano-circuits, molecular switches, molecular devices, and molecular...

Lesion bypass DNA polymerases replicate across non-DNA segments

Maor-Shoshani, Ayelet, Ben-Ari, Vered, Livneh, Zvi

A critical feature of the robustness of the DNA replication machinery is the ability to complete its task in the presence of interfering DNA damage. A key mechanism responsible for this task is...